Citation: | XIN Tong, SUN Yue, HU Jing. Research Progress on Relation Between BTBP1 and Tumor Progression and Treatment[J]. Cancer Research on Prevention and Treatment, 2022, 49(7): 715-720. DOI: 10.3971/j.issn.1000-8578.2022.21.1179 |
PTBP1, a widely-studied RNA binding protein, regulates mRNA splicing, translation, stability and localization. PTBP1 participates in a variety of ncRNA acting processes, affects tumorigenesis and tumor progression. In terms of tumor therapy, PTBP1 may act as a key factor to affect the target of targeted drugs and influence tumor resistance. This article reviews the role of PTBP1 in tumor and its research progress in tumor treatment.
Competing interests: The authors declare that they have no competing interests.
[1] |
Ontiveros RJ, Hernandez L, Nguyen H, et al. Identification and Characterization of a Minimal Functional Splicing Regulatory Protein, PTBP1[J]. Biochemistry, 2020, 59(50): 4766-4774. doi: 10.1021/acs.biochem.0c00664
|
[2] |
Spellman R, Llorian M, Smith CW. Crossregulation and functional redundancy between the splicing regulator PTB and its paralogs nPTB and ROD1[J]. Mol Cell, 2007, 27(3): 420-434. doi: 10.1016/j.molcel.2007.06.016
|
[3] |
Kim W, Shin JC, Lee KH, et al. PTBP1 Positively Regulates the Translation of Circadian Clock Gene, Period1[J]. Int J Mol Sci, 2020, 21(18): 6921. doi: 10.3390/ijms21186921
|
[4] |
Mitchell SA, Brown EC, Coldwell MJ, et al. Protein factor requirements of the Apaf-1 internal ribosome entry segment: roles of polypyrimidine tract binding protein and upstream of N-ras[J]. Mol Cell Biol, 2001, 21(10): 3364-3374. doi: 10.1128/MCB.21.10.3364-3374.2001
|
[5] |
Li B, Yen TS. Characterization of the nuclear export signal of polypyrimidine tract-binding protein[J]. J Biol Chem, 2002, 277(12): 10306-10314. doi: 10.1074/jbc.M109686200
|
[6] |
Zhu W, Zhou BL, Rong LJ, et al. Roles of PTBP1 in alternative splicing, glycolysis, and oncogensis[J]. J Zhejiang Univ Sci B, 2020, 21(2): 122-136. doi: 10.1631/jzus.B1900422
|
[7] |
沈良华, 吴璐华, 张仙丽, 等. PTBP1通过EMT途径促进肝癌细胞的迁移与侵袭[J]. 中国病理生理杂志, 2019, 35(10): 1819-1825. https://www.cnki.com.cn/Article/CJFDTOTAL-ZBLS201910013.htm
Shen LH, Wu LH, Zhang XL, et al. PTBP1 promotes migration and invasion of liver cancer cells through EMT pathway[J]. Zhongguo Bing Li Sheng Li Za Zhi, 2019, 35(10): 1819-1825. https://www.cnki.com.cn/Article/CJFDTOTAL-ZBLS201910013.htm
|
[8] |
Shen L, Lei S, Zhang B, et al. Skipping of exon 10 in Axl pre-mRNA regulated by PTBP1 mediates invasion and metastasis process of liver cancer cells[J]. Theranostics, 2020, 10(13): 5719-5735. doi: 10.7150/thno.42010
|
[9] |
He X, Arslan AD, Ho TT, et al. Involvement of polypyrimidine tract-binding protein (PTBP1) in maintaining breast cancer cell growth and malignant properties[J]. Oncogenesis, 2014, 3(1): e84. doi: 10.1038/oncsis.2013.47
|
[10] |
Jiang J, Chen X, Liu H, et al. Polypyrimidine Tract-Binding Protein 1 promotes proliferation, migration and invasion in clear-cell renal cell carcinoma by regulating alternative splicing of PKM[J]. Am J Cancer Res, 2017, 7(2): 245-259.
|
[11] |
Xie R, Chen X, Chen Z, et al. Polypyrimidine tract binding protein 1 promotes lymphatic metastasis and proliferation of bladder cancer via alternative splicing of MEIS2 and PKM[J]. Cancer Lett, 2019, 449: 31-44. doi: 10.1016/j.canlet.2019.01.041
|
[12] |
Calabretta S, Bielli P, Passacantilli I, et al. Modulation of PKM alternative splicing by PTBP1 promotes gemcitabine resistance in pancreatic cancer cells[J]. Oncogene, 2016, 35(16): 2031-2039. doi: 10.1038/onc.2015.270
|
[13] |
Tillmar L, Carlsson C, Welsh N. Control of insulin mRNA stability in rat pancreatic islets. Regulatory role of a 3'-untranslated region pyrimidine-rich sequence[J]. J Biol Chem, 2002, 277(2): 1099-1106. doi: 10.1074/jbc.M108340200
|
[14] |
Hamilton BJ, Genin A, Cron RQ, et al. Delineation of a novel pathway that regulates CD154 (CD40 ligand) expression[J]. Mol Cell Biol, 2003, 23(2): 510-525. doi: 10.1128/MCB.23.2.510-525.2003
|
[15] |
Wang MJ, Lin S. A region within the 5'-untranslated region of hypoxia-inducible factor-1alpha mRNA mediates its turnover in lung adenocarcinoma cells[J]. J Biol Chem, 2009, 284(52): 36500-36510. doi: 10.1074/jbc.M109.008904
|
[16] |
Cho CY, Chung SY, Lin S, et al. PTBP1-mediated regulation of AXL mRNA stability plays a role in lung tumorigenesis[J]. Sci Rep, 2019, 9(1): 16922. doi: 10.1038/s41598-019-53097-2
|
[17] |
Cho S, Kim JH, Back SH, et al. Polypyrimidine tract-binding protein enhances the internal ribosomal entry site-dependent translation of p27Kip1 mRNA and modulates transition from G1 to S phase[J]. Mol Cell Biol, 2005, 25(4): 1283-1297. doi: 10.1128/MCB.25.4.1283-1297.2005
|
[18] |
Galbán S, Kuwano Y, Pullmann JR, et al. RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha[J]. Mol Cell Biol, 2008, 28(1): 93-107. doi: 10.1128/MCB.00973-07
|
[19] |
Cui J, Placzek WJ. PTBP1 modulation of MCL1 expression regulates cellular apoptosis induced by antitubulin chemotherapeutics[J]. Cell Death Differ, 2016, 23(10): 1681-1690. doi: 10.1038/cdd.2016.60
|
[20] |
Matus-nicodemos R, Vavassori S, Castro-faix M, et al. Polypyrimidine tract-binding protein is critical for the turnover and subcellular distribution of CD40 ligand mRNA in CD4+ T cells[J]. J Immunol, 2011, 186(4): 2164-2171. doi: 10.4049/jimmunol.1003236
|
[21] |
Taniguchi K, Sakai M, Sugito N, et al. PTBP1-associated microRNA-1 and -133b suppress the Warburg effect in colorectal tumors[J]. Oncotarget, 2016, 7(14): 18940-18952. doi: 10.18632/oncotarget.8005
|
[22] |
Huan L, Guo T, Wu Y, et al. Hypoxia induced LUCAT1/PTBP1 axis modulates cancer cell viability and chemotherapy response[J]. Mol Cancer, 2020, 19(1): 11. doi: 10.1186/s12943-019-1122-z
|
[23] |
Zhu L, Wei Q, Qi Y, et al. PTB-AS, a Novel Natural Antisense Transcript, Promotes Glioma Progression by Improving PTBP1 mRNA Stability with SND1[J]. Mol Ther, 2019, 27(9): 1621-1637. doi: 10.1016/j.ymthe.2019.05.023
|
[24] |
Taniguchi K, Sugito N, Shinohara H, et al. Organ-Specific MicroRNAs (MIR122, 137, and 206) Contribute to Tissue Characteristics and Carcinogenesis by Regulating Pyruvate Kinase M1/2 (PKM) Expression[J]. Int J Mol Sci, 2018, 19(5): 1276. doi: 10.3390/ijms19051276
|
[25] |
Dahai Z, Daliang C, Famu L, et al. Lowly expressed lncRNA PVT1 suppresses proliferation and advances apoptosis of glioma cells through up-regulating microRNA-128-1-5p and inhibiting PTBP1[J]. Brain Res Bull, 2020, 163: 1-13. doi: 10.1016/j.brainresbull.2020.06.006
|
[26] |
Zhang C, Zhang X, Wang J, et al. Lnc00462717 regulates the permeability of the blood-brain tumor barrier through interaction with PTBP1 to inhibit the miR-186-5p/Occludin signaling pathway[J]. FASEB J, 2020, 34(8): 9941-9958. doi: 10.1096/fj.202000045R
|
[27] |
Li H, Shen S, Ruan X, et al. Biosynthetic CircRNA_001160 induced by PTBP1 regulates the permeability of BTB via the CircRNA_001160/miR-195-5p/ETV1 axis[J]. Cell Death Dis, 2019, 10(12): 960. doi: 10.1038/s41419-019-2191-z
|
[28] |
Sheng J, He X, Yu W, et al. p53-targeted lncRNA ST7-AS1 acts as a tumour suppressor by interacting with PTBP1 to suppress the Wnt/β-catenin signalling pathway in glioma[J]. Cancer Lett, 2021, 503: 54-68. doi: 10.1016/j.canlet.2020.12.039
|
[29] |
Li C, Zhao Z, Zhou Z, et al. Linc-ROR confers gemcitabine resistance to pancreatic cancer cells via inducing autophagy and modulating the miR-124/PTBP1/PKM2 axis[J]. Cancer Chemother Pharmacol, 2016, 78(6): 1199-1207. doi: 10.1007/s00280-016-3178-4
|
[30] |
Zhang Q, Xu L, Wang J, et al. KDM5C Expedites Lung Cancer Growth and Metastasis Through Epigenetic Regulation of MicroRNA-133a[J]. Onco Targets Ther, 2021, 14: 1187-1204. doi: 10.2147/OTT.S288799
|
[31] |
Wu Z, Jiang H, Fu H, et al. A circGLIS3/miR-644a/PTBP1 positive feedback loop promotes the malignant biological progressions of non-small cell lung cancer[J]. Am J Cancer Res, 2021, 11(1): 108-122.
|
[32] |
Zhang Q, Wu J, Zhang X, et al. Transcription factor ELK1 accelerates aerobic glycolysis to enhance osteosarcoma chemoresistance through miR-134/PTBP1 signaling cascade[J]. Aging (Albany NY), 2021, 13(5): 6804-6819.
|
[33] |
Minami K, Taniguchi K, Sugito N, et al. MiR-145 negatively regulates Warburg effect by silencing KLF4 and PTBP1 in bladder cancer cells[J]. Oncotarget, 2017, 8(20): 33064-33077. doi: 10.18632/oncotarget.16524
|
[34] |
Jiang D, Zhang Y, Yang L, et al. Long noncoding RNA HCG22 suppresses proliferation and metastasis of bladder cancer cells by regulation of PTBP1[J]. J Cell Physiol, 2020, 235(2): 1711-1722. doi: 10.1002/jcp.29090
|
[35] |
Xiao M, Liu J, Xiang L, et al. MAFG-AS1 promotes tumor progression via regulation of the HuR/PTBP1 axis in bladder urothelial carcinoma[J]. Clin Transl Med, 2020, 10(8): e241.
|
[36] |
Kang H, Heo S, Shin JJ, et al. A miR-194/PTBP1/CCND3 axis regulates tumor growth in human hepatocellular carcinoma[J]. J Pathol, 2019, 249(3): 395-408. doi: 10.1002/path.5325
|
[37] |
Han M, Qian X, Cao H, et al. lncRNA ZNF649-AS1 Induces Trastuzumab Resistance by Promoting ATG5 Expression and Autophagy[J]. Mol Ther, 2020, 28(11): 2488-2502. doi: 10.1016/j.ymthe.2020.07.019
|
[38] |
Zhang X, Zhou Y, Chen S, et al. LncRNA MACC1-AS1 sponges multiple miRNAs and RNA-binding protein PTBP1[J]. Oncogenesis, 2019, 8(12): 73.
|
[39] |
Zhang S, Wan H, Zhang X. LncRNA LHFPL3-AS1 contributes to tumorigenesis of melanoma stem cells via the miR-181a-5p/BCL2 pathway[J]. Cell Death Dis, 2020, 11(11): 950.
|
[40] |
Ferraese R, Harshg RT, Yadva AK, et al. Lineage-specific splicing of a brain-enriched alternative exon promotes glioblastoma progression[J]. J Clin Invest, 2014, 124(7): 2861-2876.
|
[41] |
Hwang SR, Murga-zamalloa C, Brown N, et al. Pyrimidine tract-binding protein 1 mediates pyruvate kinase M2-dependent phosphorylation of signal transducer and activator of transcription 3 and oncogenesis in anaplastic large cell lymphoma[J]. Lab Invest, 2017, 97(8): 962-970.
|
[42] |
Wang X, Li Y, Fan Y, et al. PTBP1 promotes the growth of breast cancer cells through the PTEN/Akt pathway and autophagy[J]. J Cell Physiol, 2018, 233(11): 8930-8939.
|
[43] |
Coles LS, Bartley MA, Bert A, et al. A multi-protein complex containing cold shock domain (Y-box) and polypyrimidine tract binding proteins forms on the vascular endothelial growth factor mRNA. Potential role in mRNA stabilization[J]. Eur J Biochem, 2004, 271(3): 648-660.
|
[44] |
Cheng C, Xie Z, Li Y, et al. PTBP1 knockdown overcomes the resistance to vincristine and oxaliplatin in drug-resistant colon cancer cells through regulation of glycolysis[J]. Biomed Pharmacother, 2018, 108: 194-200.
|
[45] |
Cheng C, Ding Q, Zhang Z, et al. PTBP1 modulates osteosarcoma chemoresistance to cisplatin by regulating the expression of the copper transporter SLC31A1[J]. J Cell Mol Med, 2020, 24(9): 5274-5289.
|
[46] |
He X, Sheng J, Yu W, et al. LncRNA MIR155HG Promotes Temozolomide Resistance by Activating the Wnt/β-Catenin Pathway Via Binding to PTBP1 in Glioma[J]. Cell Mol Neurobiol, 2021, 41(6): 1271-1284.
|
Tables(1)