|
|
|
|
|
Predictive Value of Depth of Invasion of Tongue Squamous Cell Carcinoma for Cervical Lymph Node Metastasis and Prognosis |
| XIA Lili1,2, ZHU Xinyi3, ZHANG Xiwei2, LI Zhengjiang2, LIU Shaoyan2, LU Haizhen3, AN Changming2 |
| 1. Xinxiang Medical University, Xinxiang 453000, China; 2. Department of Head and Neck Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China; 3. Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China |
|
|
|
Abstract Objective To investigate the predictive value of depth of invasion (DOI) of tongue squamous cell carcinoma (TSCC) for cervical lymph node metastasis and prognosis. Methods We retrospectively analyzed the clinical and pathological data of 73 patients with T1/2 TSCC. ROC curve was used to determine the optimal cut-off value of DOI for predicting cervical lymph node metastasis, and logistic regression analysis was performed to analyze the related factors affecting cervical lymph node metastasis of TSCC. Kaplan-Meier method and Cox regression analysis were used for survival analysis. Results Among 73 patients, 18 patients were with lymph node metastasis and 55 patients were without lymph node metastasis. The median DOI with and without lymph node metastasis were 8.00 and 5.00 mm, respectively (P=0.003). The optimal cut-off value for DOI was 6.15 mm, with AUC 0.75 (95%CI: 64.1%~87.1%, P=0.001), sensitivity 77.8% and specificity 63.6%. DOI and pathological differentiation were independent prognostic factors for cervical lymph node metastasis in multivariate analysis. DOI, nerve invasion and pathological differentiation were independent prognostic factors of survival in Cox regression analysis. Conclusion DOI of TSCC patients has important predictive value for both cervical lymph node metastasis and prognosis. Neck lymph node dissection is recommended for patients with DOI>6.15 mm to improve survival rate and reduce recurrence rate.
|
| Keywords
Tongue squamous cell cancer
Depth of invasion
Cervical lymph node metastasis
Prognosis
|
|
|
| Fund:Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences (No. 2019-C-HL-004); Beijing Hope Run Special Fund of Cancer Foundation of China (No. LC2018L06, No. LC2020A19) |
|
Issue Date: 14 July 2022
|
|
[1] Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019[J]. CA
Cancer J Clin, 2019, 69(1): 7-34.
[2] Siegel RL, Miller KD, Jemal A. Cancer Statistics, 2020[J]. CA
Cancer J Clin, 2020, 70(1): 7-30.
[3] Takayuki Imai, Ikuro Satoh, Ko Matsumoto, et al. Retrospective
observational study of occult cervical lymph-node metastasis in
T1N0 tongue cancer[J]. Jpn J Clin Oncol, 2017, 47(2): 130-136.
[4] Berdugo J, Thompson LDR, Purgina B, et al. Measuring Depth of
Invasion in Early Squamous Cell Carcinoma of the Oral Tongue:
Positive Deep Margin, Extratumoral Perineural Invasion, and
Other Challenges[J]. Head Neck Pathol, 2019, 13(2): 154-161.
[5] Haraguchi K, Yoshiga D, Oda M, et al. Depth of invasion
determined by magnetic resonance imaging in tongue cancer can
be a predictor of cervical lymph node metastasis[J]. Oral Surg
Oral Med Oral Pathol Oral Radiol, 2021, 131(2): 231-240.
[6] Liebig C, Ayala G, Wilks JA, et al. Perineural invasion in cancer: a
review of the literature [J]. Cancer, 2009, 115(15): 3379-3391.
[7] Keski-S?ntti H, Atula T, Tikka J, et al. Predictive value of
histopathologic parameters in early squamous cell carcinoma of
oral tongue[J]. Oral Oncol, 2007, 43(10): 1007-1013.
[8] Xu B, Salama AM, Valero C, et al. The prognostic role of histologic
grade, worst pattern of invasion, and tumor budding in early
oral tongue squamous cell carcinoma: a comparative study[J].
Virchows Arch, 2021, 479(3): 597-606.
[9] Lugli A, Kirsch R, Ajioka Y, et al. Recommendations for reporting
tumor budding in colorectal cancer based on the International
Tumor Budding Consensus Conference (ITBCC) 2016[J]. Mod
Pathol, 2017, 30(9): 1299-1311.
[10] 何升腾, 焦晓辉, 刘欧胜, 等. 1171例舌癌的治疗与预后分析[J].
重庆医学, 2014, 43(6): 671-673. [He ST, Jiao XH, Liu OS, et al.
Clinical analysis of treatment and prognosis on 1171 cases of
tongue carcinoma[J]. Chongqing Yi Xue, 2014, 43(6): 671-673.]
[11] 隋馥勇, 张褔胤. 影响早期舌鳞状细胞癌颈部淋巴结转移相关
因素研究[J]. 现代口腔医学杂志, 2020, 34(1): 10-13. [Sui FY,
Zhang FY. Influence on factors related to cervical lymph node
metastasis of early tongue squamous cell carcinoma[J]. Xian Dai
Kou Qiang Yi Xue Za Zi, 2020, 34(1): 10-13.]
[12] Tam S, Amit M, Zafereo M, et al. Depth of invasion as a predictor
of nodal disease and survival in patients with oral tongue
squamous cell carcinoma[J]. Head Neck, 2019, 41(1): 177-184.
[13] O-charoenrat P, Pillai G, Patel S, et al. Tumour thickness predicts
cervical nodal metastases and survival in early oral tongue
cancer[J]. Oral Oncol, 2003, 39(4): 386-390.
[14] 安常明, 张彬, 徐震纲, 等. 口舌鳞状细胞癌复发因素分析[J]. 中
国肿瘤临床, 2008, 35(21): 1216-1219. [An CM, Zhang B, Xu
ZG, et al. Analysis of Factors about Recurrence of Oral Tongue
Squamous Cell Carcinomas[J]. Zhongguo Zhong Liu Lin Chuang,
2008, 35(21): 1216-1219.]
[15] Kademani D, Bell RB, Bagheri S, et al. Prognostic factors in
intraoral squamous cell carcinoma: the influence of histologic
grade[J]. J Oral Maxillofac Surg, 2005, 63(11): 1599-1605.
[16] Larsen SR, Johansen J, S?rensen JA, et al. The prognostic
significance of histological features in oral squamous cell
carcinoma[J]. J Oral Pathol Med, 2009, 38(8): 657-662.
[17] Karjol U, Jonnada P, Annavarjula V, et al. Prognostic Role of
Tumor Budding in Carcinoma Tongue: A Systemic Review and
Meta-Analysis[J]. Reus, 2020, 12(7): e9316.
[18] Bjerkli IH, Laurvik H, Nginamau ES, et al. Tumor budding
score predicts lymph node status in oral tongue squamous cell
carcinoma and should be included in the pathology report[J].
PLoS One, 2020, 15(9): e0239783.
[19] McMahon JD, Pitts R, Isbister J, et al. Postoperative risk
stratification in oral squamous cell carcinoma[J]. Brit J Oral
Maxillofac Surg, 2020, 58(4): 462-468.
[20] Tai SK, Li WY, Chu PY, et al. Risks and clinical implications
of perineural invasion in T1-2 oral tongue squamous cell
carcinoma[J]. Head Neck, 2012, 34: 994-1001.
[21] Chen TC, Wang CP, Ko JY, et al. The impact of perineural
invasion and/or lymphovascular invasion on the survival of earlystage
oral squamous cell carcinoma patients[J]. Ann Surg Oncol,
2013, 20(7): 2388-2395.
[22]Barrett AW, Pratt MK, Sassoon I, et al. Perineural and
lymphovascular invasion in squamous cell carcinoma of the
tongue[J]. J Oral Pathol Med, 2021, 50(1): 32-38.
[23] 李明, 南欣荣, 原振英, 等. 磁共振成像评估舌鳞状细胞癌浸润
深度的准确性分析[J]. 口腔疾病防治, 2021, 29(5): 322-327. [Li
M, Nan XR, Yan ZY, et al. Accuracy analysis of MRI in the depth
of invasion assessment of tongue squamous cell carcinoma[J].
Kou Qiang Ji Bing Fang Zhi, 2021, 29(5): 322-327.]
[24] Fu JY, Zhu L, Li J, et al. Assessing the magnetic resonance
imaging in determining the depth of invasion of tongue cancer[J].
Oral Dis, 2021, 27(3): 457-463. |
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
| |
Shared |
|
|
|
|
| |
Discussed |
|
|
|
|
