| Citation: |
XU Gang, BU Shanshan, WANG Xiushen, GE Hong. Correlation Between cyclin G1 Expression and Efficacy of Radiotherapy on Primary Hepatocellular Carcinoma[J]. Cancer Research on Prevention and Treatment, 2021, 48(10): 958-962. DOI: 10.3971/j.issn.1000-8578.2021.21.0316
|
To investigate the correlation between cyclin G1 expression and the efficacy of radiotherapy on HCC.
The expression of cyclin G1 in biopsy specimens of 68 patients who received radiotherapy was detected by immunochemistry. The correlation between cyclin G1 expression and clinicopathological characteristics was analyzed by chi-square test. The correlation between cyclin G1 expression and OS or PFS was evaluated by Kaplan-Meier analysis. Univariate and multivariate analyses were used for the relation between clinicopathological characteristics and OS or PFS.
The expression of cyclin G1 was related to portal vein tumor embolus, clinical stage and alpha fetoprotein. Survival analysis showed that the OS and PFS of patients with low expression of cyclin G1 were significantly higher than those with high cyclin G1 expression (P < 0.05). Multivariate analysis showed that cyclin G1 was an independent risk factor for DFS of patients with HCC.
High expression of cyclin G1 is an adverse prognostic factor for HCC patients who received radiotherapy.
Competing interests: The authors declare that they have no competing interests.
| [1] |
Vogel A, Saborowski A. Current strategies for the treatment of intermediate and advanced hepatocellular carcinoma[J]. Cancer Treat Rev, 2020, 82: 101946. doi: 10.1016/j.ctrv.2019.101946
|
| [2] |
Forner A, Reig M, Bruix J. Hepatocellular carcinoma[J]. Lancet, 2018, 391(10127): 1301-1314. doi: 10.1016/S0140-6736(18)30010-2
|
| [3] |
马中山, 马云玲, 冯丽. 放疗在原发性肝癌非手术治疗中的地位与作用[J]. 中华放射医学与防护杂志, 2010, 30(1): 102-104. doi: 10.3760/cma.j.issn.0254-5098.2010.01.035
Ma ZH, Ma YL, Feng L. The role of radiotherapy in non-surgical treatment of primary liver cancer[J]. Zhonghua Fang She Yi Xue Yu Fang Hu Za Zhi, 2010, 30(1): 102-104. doi: 10.3760/cma.j.issn.0254-5098.2010.01.035
|
| [4] |
Park S, Yoon WS, Rim CH. Indications of external radiotherapy for hepatocellular carcinoma from updated clinical guidelines: Diverse global viewpoints[J]. World J Gastroenterol, 2020, 26(4): 393-403. doi: 10.3748/wjg.v26.i4.393
|
| [5] |
Choi SH, Seong J. Strategic application of radiotherapy for hepatocellular carcinoma[J]. Clin Mol Hepatol, 2018, 24(2): 114-134. doi: 10.3350/cmh.2017.0073
|
| [6] |
Kimura SH, Ikawa M, Ito A, et al. Cyclin G1 is involved in G2/M arrest in response to DNA damage and in growth control after damage recovery[J]. Oncogene, 2001, 20(25): 3290-3300. doi: 10.1038/sj.onc.1204270
|
| [7] |
许刚, 王燕, 吴立广, 等. Cyclin G1对肝癌细胞HepG2放射敏感度的影响及其机制[J]. 肿瘤防治研究, 2017, 44(9): 590-595. doi: 10.3971/j.issn.1000-8578.2017.17.0039
Xu G, Wang Y, Wu LG, et al. Effect of cyclin G1 on radiosensitivity of hepatocellular carcinoma HepG2 cells and its mechanism[J]. Zhoong Liu Fang Zhi Yan Jiu, 2017, 44(9): 590-595. doi: 10.3971/j.issn.1000-8578.2017.17.0039
|
| [8] |
Choi C, Koom WS, Kim TH, et al. A prospective phase 2 multicenter study for the efficacy of radiation therapy following incomplete transarterial chemoembolization in unresectable hepatocellular carcinoma[J]. Int J Radiat Oncol Biol Phys, 2014, 90(5): 1051-1060. doi: 10.1016/j.ijrobp.2014.08.011
|
| [9] |
Honda Y, Kimura T, Aikata H, et al. Stereotactic body radiation therapy combined with transcatheter arterial chemoembolization for small hepatocellular carcinoma[J]. J Gastroenterol Hepatol, 2013, 28(3): 530-536. doi: 10.1111/jgh.12087
|
| [10] |
Wahl DR, Stenmark MH, Tao Y, et al. Outcomes After Stereotactic Body Radiotherapy or Radiofrequency Ablation for Hepatocellular Carcinoma[J]. J Clin Oncol, 2016, 34(5): 452-459. doi: 10.1200/JCO.2015.61.4925
|
| [11] |
Wei X, Jiang Y, Zhang X, et al. Neoadjuvant Three-Dimensional Conformal Radiotherapy for Resectable Hepatocellular Carcinoma With Portal Vein Tumor Thrombus: A Randomized, Open-Label, Multicenter Controlled Study[J]. J Clin Oncol, 2019, 37(24): 2141-2151. doi: 10.1200/JCO.18.02184
|
| [12] |
Liu PH, Hsu CY, Hsia CY, et al. Prognosis of hepatocellular carcinoma: Assessment of eleven staging systems[J]. J Hepatol, 2016, 64(3): 601-608. doi: 10.1016/j.jhep.2015.10.029
|
| [13] |
Wang CY, Li S. Clinical characteristics and prognosis of 2887 patients with hepatocellular carcinoma: A single center 14 years experience from China[J]. Medicine (Baltimore), 2019, 98(4): e14070. doi: 10.1097/MD.0000000000014070
|
| [14] |
田小强, 鲁世慧, 王礼学, 等. 不可手术的原发性肝癌放疗效果影响因素及预后分析[J]. 东南大学学报(医学版), 2019, 38(6): 1029-1034. doi: 10.3969/j.issn.1671-6264.2019.06.019
Tian XQ, Lu SH, Wang LX, et al. Analysis of efficiency and influence factor of intensity-modulated radiotherapy for inoperable primary hepatocellular carcinoma[J]. Dongnan Da Xue Xue Bao(Yi Xue Ban), 2019, 38(6): 1029-1034. doi: 10.3969/j.issn.1671-6264.2019.06.019
|
| [15] |
田璐, 吴炯, 朱捷, 等. C5L2表达与肝癌患者预后分析[J]. 复旦学报(医学版), 2017, 44(3): 280-287. doi: 10.3969/j.issn.1672-8467.2017.03.005
Tian L, Wu J, Zhu J, et al. Prognostic analysis of C5L2 in patients with hepatocellular carcinoma[J]. Fu Dan Xue Bao(Yi Xue Ban), 2017, 44(3): 280-287. doi: 10.3969/j.issn.1672-8467.2017.03.005
|
| [16] |
Deng Y, Zhou X, Xiang X, et al. NOR1 expression and its relationship with prognosis in patients with hepatocellular carcinoma[J]. J BUON, 2017, 22(5): 1186-1190. http://www.jbuon.com/pdfs/1186-1190.pdf
|
| [17] |
Zhao X, Chen Y, Mao Q, et al. Overexpression of YTHDF1 is associated with poor prognosis in patients with hepatocellular carcinoma[J]. Cancer Biomark, 2018, 21(4): 859-868. doi: 10.3233/CBM-170791
|
| [18] |
Chawla SP, Bruckner H, Morse MA, et al. A Phase Ⅰ-Ⅱ Study Using Rexin-G Tumor-Targeted Retrovector Encoding a Dominant-Negative Cyclin G1 Inhibitor for Advanced Pancreatic Cancer[J]. Mol Ther Oncolytics, 2018, 12: 56-67.
|
| [19] |
Yan J, Jiang JY, Meng XN, et al. MiR-23b targets cyclin G1 and suppresses ovarian cancer tumorigenesis and progression[J]. J Exp Clin Cancer Res, 2016, 35: 31. doi: 10.1186/s13046-016-0307-1
|
| [20] |
Wen W, Ding J, Sun W, et al. Cyclin G1-mediated epithelial-mesenchymal transition via phosphoinositide 3-kinase/Akt signaling facilitates liver cancer progression[J]. Hepatology, 2012, 55(6): 1787-1798. doi: 10.1002/hep.25596
|
| [21] |
Xu L, Lin X, Zheng Y, et al. Silencing of heat shock protein 27 increases the radiosensitivity of non-small cell lung carcinoma cells[J]. Mol Med Rep, 2019, 20(1): 613-621.
|
Figures(2) / Tables(3)
This work is licensed under a Creative Commons Attribution 3.0 License.
Copyright © Editorial Department of Cancer Prevention Research 鄂公网安备 42011102005013号 鄂ICP备2022015867号
Supported by: Beijing Renhe Information Technology Co., Ltd. 
DownLoad: