| Citation: |
LI Huan, CAO Lu, CHEN Jiayi. Relationship Between Heart Irradiation Dose-volume and Radiation-induced Cardiac Toxicity in Radiotherapy for Thoracic Neoplasms[J]. Cancer Research on Prevention and Treatment, 2018, 45(11): 841-846. DOI: 10.3971/j.issn.1000-8578.2018.18.1023
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Radiation therapy is one of the important systematic treatment strategies for thoracic neoplasms, but it also can cause a definite cardiac toxicity. With the evolution of main radiotherapeutic technology, the characteristics of heart irradiation dose-volume distribution in patients with thoracic tumor receiving radiotherapy have been changed. The incidence of radiation-related heart diseases (RRHDs) has been significantly decreased. However, precise radiotherapy based on intensity modulated radiation therapy still can not guarantee the absolute cardiac safety currently. This article reviews the effect of heart irradiation dose-volume distribution on potential risks of RRHDs, and the parameters to evaluate heart doses and volume, as well as other techniques affecting the dose-volume distribution of heart irradiation and the detection of RRHDs.
| [1] |
Delaney G, Jacob S, Featherstone C, et al. The role of radiotherapy in cancer treatment: estimating optimal utilization from a review of evidence-based clinical guidelines[J]. Cancer, 2005, 104(6): 1129-37. doi: 10.1002/(ISSN)1097-0142
|
| [2] |
Clarke M, Collins R, Darby S, et al. Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials[J]. Lancet, 2005, 366(9503): 2087-106. doi: 10.1016/S0140-6736(05)67887-7
|
| [3] |
Ng AK. Review of the cardiac long-term effects of therapy for Hodgkin lymphoma[J]. Br J Haematol, 2011, 154(1): 23-31. doi: 10.1111/bjh.2011.154.issue-1
|
| [4] |
Lipshultz SE, Adams MJ, Colan SD, et al. Long-term cardiovascular toxicity in children, adolescents, and young adults who receive cancer therapy: pathophysiology, course, monitoring, management, prevention, and research directions: a scientific statement from the American Heart Association[J]. Circulation, 2013, 128(17): 1927-95. doi: 10.1161/CIR.0b013e3182a88099
|
| [5] |
Gagliardi G, Constine LS, Moiseenko V, et al. Radiation dose–volume effects in the heart[J]. Int J Radiat Oncol Biol Phys, 2010, 76(3 Suppl): S77-S85. http://d.old.wanfangdata.com.cn/OAPaper/oai_doaj-articles_1617116e880b70e7ed02c3da26286382
|
| [6] |
Hardenbergh PH, Munley MT, Bentel GC, et al. Cardiac perfusion changes in patients treated for breast cancer with radiation therapy and doxorubicin: preliminary results[J]. Int J Radiat Oncol Biol Phys, 2001, 49(4): 1023-8. doi: 10.1016/S0360-3016(00)01531-5
|
| [7] |
Sardar P, Kundu A, Chatterjee S, et al. Long-term cardiovascular mortality after radiotherapy for breast cancer: A systematic review and meta-analysis[J]. Clin Cardiol, 2017, 40(2): 73-81. doi: 10.1002/clc.2017.40.issue-2
|
| [8] |
Maraldo MV, Brodin NP, Vogelius IR, et al. Risk of developing cardiovascular disease after involved node radiotherapy versus mantle field for Hodgkin lymphoma[J]. Int J Radiat Oncol Biol Phys, 2012, 83(4): 1232-7. doi: 10.1016/j.ijrobp.2011.09.020
|
| [9] |
Tan W, Wang X, Qiu D, et al. Dosimetric comparison of intensity-modulated radiotherapy plans, with or without anterior myocardial territory and left ventricle as organs at risk, in early-stage left-sided breast cancer patients[J]. Int J Radiat Oncol Biol Phys, 2011, 81(5): 1544-51. doi: 10.1016/j.ijrobp.2010.09.028
|
| [10] |
Coon AB, Dickler A, Kirk MC, et al. Tomotherapy and multifield intensity-modulated radiotherapy planning reduce cardiac doses in left-sided breast cancer patients with unfavorable cardiac anatomy[J]. Int J Radiat Oncol Biol Phys, 2010, 78(1): 104-10. doi: 10.1016/j.ijrobp.2009.07.1705
|
| [11] |
Ma J, Li J, Xie J, et al. Post mastectomy linac IMRT irradiation of chest wall and regional nodes: dosimetry data and acute toxicities[J]. Radiat Oncol, 2013, 8: 81. doi: 10.1186/1748-717X-8-81
|
| [12] |
Cao L, Hu WG, Kirova YM, et al. Potential impact of cardiac dose-volume on acute cardiac toxicity following concurrent trastuzumab and radiotherapy[J]. Cancer Radiother, 2014, 18(2): 119-24. doi: 10.1016/j.canrad.2014.01.001
|
| [13] |
Cao L, Cai G, Chang C, et al. Early cardiac toxicity following adjuvant radiotherapy of left-sided breast cancer with or without concurrent trastuzumab[J]. Oncotarget, 2016, 7(1): 1042-54. http://d.old.wanfangdata.com.cn/NSTLQK/NSTL_QKJJ0232730919/
|
| [14] |
Cao L, Cai G, Chang C, et al. Diastolic Dysfunction Occurs Early in HER2-Positive Breast Cancer Patients Treated Concurrently With Radiation Therapy and Trastuzumab[J]. Oncologist, 2015, 20(6): 605-14. doi: 10.1634/theoncologist.2014-0299
|
| [15] |
Shimizu Y, Kodama K, Nishi N, et al. Radiation exposure and circulatory disease risk: Hiroshima and Nagasaki atomic bomb survivor data, 1950-2003[J]. BMJ, 2010, 340: b5349. doi: 10.1136/bmj.b5349
|
| [16] |
Darby SC, Ewertz M, Mcgale P, et al. Risk of ischemic heart disease in women after radiotherapy for breast cancer[J]. N Engl J Med, 2013, 368(11): 987-98. doi: 10.1056/NEJMoa1209825
|
| [17] |
van den Bongaard VA, Ta BD, van der Schaaf A, et al. Validation and modification of a prediction model for acute cardiac events in patients with breast cancer treated with radiotherapy based on three-dimensional dose distributions to cardiac substructures[J]. J Clin Oncol, 2017, 35(11): 1171-8. doi: 10.1200/JCO.2016.69.8480
|
| [18] |
Popescu CC, Olivotto IA, Beckham WA, et al. Volumetric modulated arc therapy improves dosimetry and reduces treatment time compared to conventional intensity-modulated radiotherapy for locoregional radiotherapy of left-sided breast cancer and internal mammary nodes[J]. Int J Radiat Oncol Biol Phys, 2010, 76(1): 287-95. doi: 10.1016/j.ijrobp.2009.05.038
|
| [19] |
Osman SO, Hol S, Poortmans PM, et al. Volumetric modulated arc therapy and breath-hold in image-guided locoregional left-sided breast irradiation[J]. Radiother Oncol, 2014, 112(1): 17-22. doi: 10.1016/j.radonc.2014.04.004
|
| [20] |
Lauche O, Kirova YM. Helical tomotherapy in breast cancer treatment[J]. Breast Cancer Management, 2014, 3(5): 441-9. doi: 10.2217/bmt.14.34
|
| [21] |
Lauche O, Kirova YM, Fenoglietto P, et al. Helical tomotherapy and volumetric modulated arc therapy: New therapeutic arms in the breast cancer radiotherapy[J]. World J Radiol, 2016, 8(8): 735-42. doi: 10.4329/wjr.v8.i8.735
|
| [22] |
Schubert LK, Gondi V, Sengbusch E, et al. Dosimetric comparison of left-sided whole breast irradiation with 3DCRT, forward-planned IMRT, inverse-planned IMRT, helical tomotherapy, and topotherapy[J]. Radiother Oncol, 2011, 100(2): 241-6. doi: 10.1016/j.radonc.2011.01.004
|
| [23] |
Taylor CW, Wang Z, Macaulay E, et al. Exposure of the Heart in Breast Cancer Radiation Therapy: A Systematic Review of Heart Doses Published During 2003 to 2013[J]. Int J Radiat Oncol Biol Phys, 2015, 93(4): 845-53. doi: 10.1016/j.ijrobp.2015.07.2292
|
| [24] |
Taylor C, Correa C, Duane FK, et al. Estimating the Risks of Breast Cancer Radiotherapy: Evidence From Modern Radiation Doses to the Lungs and Heart and From Previous Randomized Trials[J]. J Clin Oncol, 2017, 35(15): 1641-9. doi: 10.1200/JCO.2016.72.0722
|
| [25] |
Wang K, Pearlstein KA, Patchett ND, et al. Heart dosimetric analysis of three types of cardiac toxicity in patients treated on dose-escalation trials for Stage Ⅲ non-small-cell lung cancer[J]. Radiother Oncol, 2017, 125(2): 293-300. doi: 10.1016/j.radonc.2017.10.001
|
| [26] |
Kirova YM, de Almeida CE, Canary PC, et al. Heart, coronaries and breast cancer radiotherapy[J]. Breast, 2011, 20(2): 196-7. doi: 10.1016/j.breast.2010.12.002
|
| [27] |
Feng M, Moran JM, Koelling T, et al. Development and validation of a heart atlas to study cardiac exposure to radiation following treatment for breast cancer[J]. Int J Radiat Oncol Biol Phys, 2011, 79(1): 10-8. doi: 10.1016/j.ijrobp.2009.10.058
|
| [28] |
Yeung R, Conroy L, Long K, et al. Cardiac dose reduction with deep inspiration breath hold for left-sided breast cancer radiotherapy patients with and without regional nodal irradiation[J]. Radiat Oncol, 2015, 10: 200. doi: 10.1186/s13014-015-0511-8
|
| [29] |
Lymberis SC, Dewyngaert JK, Parhar P, et al. Prospective assessment of optimal individual position (prone versus supine) for breast radiotherapy: volumetric and dosimetric correlations in 100 patients[J]. Int J Radiat Oncol Biol Phys, 2012, 84(4): 902-9. doi: 10.1016/j.ijrobp.2012.01.040
|
| [30] |
Formenti SC, Dewyngaert JK, Jozsef G, et al. Prone vs supine positioning for breast cancer radiotherapy[J]. JAMA, 2012, 308(9): 861-3. doi: 10.1001/2012.jama.10759
|
| [31] |
Bronsart E, Dureau S, Xu HP, et al. Whole breast radiotherapy in the lateral isocentric lateral decubitus position: Long-term efficacy and toxicity results[J]. Radiother Oncol, 2017, 124(2): 214-9. doi: 10.1016/j.radonc.2017.07.001
|
| [32] |
Bradley JA, Dagan R, Ho MW, et al. Initial Report of a Prospective Dosimetric and Clinical Feasibility Trial Demonstrates the Potential of Protons to Increase the Therapeutic Ratio in Breast Cancer Compared With Photons[J]. Int J Radiat Oncol Biol Phys, 2016, 95(1): 411-21. doi: 10.1016/j.ijrobp.2015.09.018
|
| [33] |
Zamorano JL, Lancellotti P, Rodriguez Muñoz D, et al. 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines: The Task Force for cancer treatments and cardiovascular toxicity of the European Society of Cardiology (ESC)[J]. Eur Heart J, 2016, 37(36): 2768-801. doi: 10.1093/eurheartj/ehw211
|
| [34] |
Nishimura RA, Otto CM, Bonow RO, et al. 2017 AHA/ACC focused update of the 2014 aha/acc guideline for the management of patients with valvular heart disease: a report of the american college of cardiology/american heart association task force on clinical practice guidelines[J]. Circulation, 2017, 135(25): e1159-95. https://www.ncbi.nlm.nih.gov/pubmed/24939033
|
| [35] |
Virani SA, Dent S, Brezden-Masley C, et al. Canadian cardiovascular society guidelines for evaluation and management of cardiovascular complications of cancer therapy[J]. Can J Cardiol, 2016, 32(7): 831-41. doi: 10.1016/j.cjca.2016.02.078
|
| [36] |
Erven K, Florian A, Slagmolen P, et al. Subclinical cardiotoxicity detected by strain rate imaging up to 14 months after breast radiation therapy[J]. Int J Radiat Oncol Biol Phys, 2013, 85(5): 1172-8. doi: 10.1016/j.ijrobp.2012.09.022
|
| [37] |
Skyttä T, Tuohinen S, Boman E, et al. Troponin T-release associates with cardiac radiation doses during adjuvant left-sided breast cancer radiotherapy[J]. Radiat Oncol, 2015, 10: 141. doi: 10.1186/s13014-015-0436-2
|
| [38] |
Palumbo I, Palumbo B, Fravolini ML, et al. Brain natriuretic peptide as a cardiac marker of transient radiotherapy-related damage in left-sided breast cancer patients: A prospective study[J]. Breast, 2016, 25: 45-50. doi: 10.1016/j.breast.2015.10.004
|
| [39] |
Kozak KR, Hong TS, Sluss PM, et al. Cardiac blood biomarkers in patients receiving thoracic (chemo)radiation[J]. Lung Cancer, 2008, 62(3): 351-5. doi: 10.1016/j.lungcan.2008.03.024
|
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