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Research Progress on Combined Immunotherapy for Microsatellite Stable Colorectal Cancer#br# |
| YIN Zhucheng, LIANG Xinjun |
| Department of Medical Oncology, Hubei Cancer Hospital, Wuhan 430079, China |
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Abstract In recent years, immunotherapy has achieved great progress in the treatment of malignant tumors and has enriched the treatment mode of many types of malignant tumors. Colorectal cancer is a common tumor worldwide. Immune checkpoint inhibitor therapy for patients with metastatic colorectal cancer (mCRC) featuring DNA mismatch repair deficiency/high microsatellite instability has significant clinical benefits, but approximately 95% of patients with mCRC are DNA mismatch repair proficient/microsatellite stable (MSS). These patients have poor response to immunotherapy. Therefore, strategies to improve the efficacy of immunotherapy in patients with this type of tumor have attracted considerable attention. This article reviews the research progress on combined immunotherapy for MSS mCRC.
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| Keywords
Colorectal cancer
pMMR
MSS
Immunotherapy
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| Fund:National Natural Science Foundation of China (No. 81772499, 81572287); Wuhan Science and Technology Bureau Applied Basic Research Project (No. 2020020601012250) |
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Issue Date: 15 September 2022
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