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Advances in Tumor-associated Macrophages in Cancer Radiotherapy |
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WU Zhuochao1,2, HUANG Zhaohui1,2
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| 1. Wuxi Cancer Institute, Affiliated Hospital of Jiangnan University, Wuxi 214062, China; 2. Laboratory of Cancer Epigenetics, Wuxi School of Medicine, Jiangnan University, Wuxi 214122, China |
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Abstract Tumor-associated macrophages (TAMs) are one of the most abundant immune cells in the tumor microenvironment. As a heterogenous cell population, TAMs usually affect tumor growth, metastasis, and therapeutic resistance. Currently, TAM has attracted wide attention as a promising therapy target for human cancers. As one of the basic treatments of malignant tumors, radiotherapy can regulate the phenotypes and functions of TAM. Meanwhile, TAM can affect the response of cancer cells to radiation. This paper reviews the research advances of TAM in cancer radiotherapy.
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| Keywords
Tumor-associated macrophage
Radiotherapy
Tumor microenvironment
Radiation dose
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| Fund:National Natural Science Foundation of China (No. 81672328) |
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Issue Date: 14 September 2022
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