Cancer Research on Prevention and Treatment    2022, Vol. 49 Issue (07) : 675-681     DOI: 10.3971/j.issn.1000-8578.2022.21.1460
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Predictive Value of Depth of Invasion of Tongue Squamous Cell Carcinoma for Cervical Lymph Node Metastasis and Prognosis
XIA Lili1,2, ZHU Xinyi3, ZHANG Xiwei2, LI Zhengjiang2, LIU Shaoyan2, LU Haizhen3, AN Changming2
1. Xinxiang Medical University, Xinxiang 453000, China; 2. Department of Head and Neck Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China; 3. Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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Abstract Objective To investigate the predictive value of depth of invasion (DOI) of tongue squamous cell carcinoma (TSCC) for cervical lymph node metastasis and prognosis. Methods We retrospectively analyzed the clinical and pathological data of 73 patients with T1/2 TSCC. ROC curve was used to determine the optimal cut-off value of DOI for predicting cervical lymph node metastasis, and logistic regression analysis was performed to analyze the related factors affecting cervical lymph node metastasis of TSCC. Kaplan-Meier method and Cox regression analysis were used for survival analysis. Results Among 73 patients, 18 patients were with lymph node metastasis and 55 patients were without lymph node metastasis. The median DOI with and without lymph node metastasis were 8.00 and 5.00 mm, respectively (P=0.003). The optimal cut-off value for DOI was 6.15 mm, with AUC 0.75 (95%CI: 64.1%~87.1%, P=0.001), sensitivity 77.8% and specificity 63.6%. DOI and pathological differentiation were independent prognostic factors for cervical lymph node metastasis in multivariate analysis. DOI, nerve invasion and pathological differentiation were independent prognostic factors of survival in Cox regression analysis. Conclusion DOI of TSCC patients has important predictive value for both cervical lymph node metastasis and prognosis. Neck lymph node dissection is recommended for patients with DOI>6.15 mm to improve survival rate and reduce recurrence rate.
Keywords Tongue squamous cell cancer      Depth of invasion      Cervical lymph node metastasis      Prognosis     
ZTFLH:  R739.86  
Fund:Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences (No. 2019-C-HL-004); Beijing Hope Run Special Fund of Cancer Foundation of China (No. LC2018L06, No. LC2020A19)
Issue Date: 14 July 2022
 Cite this article:   
XIA Lili,ZHU Xinyi,ZHANG Xiwei, et al. Predictive Value of Depth of Invasion of Tongue Squamous Cell Carcinoma for Cervical Lymph Node Metastasis and Prognosis[J]. Cancer Research on Prevention and Treatment, 2022, 49(07): 675-681.
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http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2022.21.1460
http://www.zlfzyj.com/EN/Y2022/V49/I07/675
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XIA Lili
ZHU Xinyi
ZHANG Xiwei
LI Zhengjiang
LIU Shaoyan
LU Haizhen
AN Changming
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