Cancer Research on Prevention and Treatment    2022, Vol. 49 Issue (07) : 721-726     DOI: 10.3971/j.issn.1000-8578.2022.21.1281
Current Status and Prospects of Immunotherapy for Osteosarcoma
WU Wei, JING Doudou, CAO Li, PU Feifei, SHAO Zengwu
Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
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Abstract Osteosarcoma is a malignant tumor with extreme invasiveness and metastasis as well as dismal prognosis. It is critical to rapidly find a unique therapy strategy capable of significantly improving the prognosis of osteosarcoma. Tumor immunotherapy has the potential to reawaken the immune system, restart and sustain the tumor-immune cycle in the body, resulting in the death of tumor cells. CD8+ CTL, CD4+ T cells, NK cells and NKT cells all play critical roles in tumor immunity, while humoral immunity may not only inhibit tumor growth but also enhance it. Researchers have devised various strategies to boost the immune system in recent years based on tumor immune response studies. This paper highlights and examines osteosarcoma immunotherapy from two perspectives: (1) boosting the response of patient’s own immune system to the tumor; (2) exogenously improving the patient’s immunological function.
Keywords Osteosarcoma      Tumor immune escape      Immunotherapy     
ZTFLH:  R738.1  
Fund:National Natural Science Funding of China (No. 81904231); China Postdoctoral Science Foundation (No. 2020M672369)
Issue Date: 14 July 2022
 Cite this article:   
WU Wei,JING Doudou,CAO Li, et al. Current Status and Prospects of Immunotherapy for Osteosarcoma[J]. Cancer Research on Prevention and Treatment, 2022, 49(07): 721-726.
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WU Wei
JING Doudou
PU Feifei
SHAO Zengwu
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