Cancer Research on Prevention and Treatment    2018, Vol. 45 Issue (11) : 847-851     DOI: 10.3971/j.issn.1000-8578.2018.18.0887
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Technical Prevention of Radiation-induced Cardiovascular Toxicity
WANG Xuanyi, YU Xiaoli
Department of Radiation Oncology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China
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Abstract Radiotherapy has been an important component of cancer treatment. In the malignancy with long survival, radiation-induced cardiovascular toxicity significantly jeopardize patients’ outcome. Despite that its pathophysiological mechanism is not clear yet, many studies have confirmed the positive correlation between cardiovascular involvement dose, irradiated volume and radiation-induced cardiotoxicity. Therefore, reducing cardiovascular involvement dose as well as irradiated volume is the key to cardiac sparing techniques in radiotherapy. Cardiac sparing techniques includes: (1) methods that reduce radiation fields and dose; (2) methods that increase the distance between heart and irradiated fields; (3) new techniques such as intensity modulated radiotherapy and proton therapy. Although researches in dosimetry have showed that cardiac sparing techniques could lower cardiovascular involvement dose and irradiated volume, further validation is needed for curative effect.
Keywords Radiotherapy      Radiation-induced cardiovascular toxicity      Cardiac sparing technique     
ZTFLH:  R732  
  R730.55  
Issue Date: 14 November 2018
 Cite this article:   
WANG Xuanyi,YU Xiaoli. Technical Prevention of Radiation-induced Cardiovascular Toxicity[J]. Cancer Research on Prevention and Treatment, 2018, 45(11): 847-851.
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http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2018.18.0887
http://www.zlfzyj.com/EN/Y2018/V45/I11/847
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