|
|
|
|
|
Technical Prevention of Radiation-induced Cardiovascular Toxicity |
| WANG Xuanyi, YU Xiaoli |
| Department of Radiation Oncology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China |
|
|
|
|
Abstract Radiotherapy has been an important component of cancer treatment. In the malignancy with long survival, radiation-induced cardiovascular toxicity significantly jeopardize patients’ outcome. Despite that its pathophysiological mechanism is not clear yet, many studies have confirmed the positive correlation between cardiovascular involvement dose, irradiated volume and radiation-induced cardiotoxicity. Therefore, reducing cardiovascular involvement dose as well as irradiated volume is the key to cardiac sparing techniques in radiotherapy. Cardiac sparing techniques includes: (1) methods that reduce radiation fields and dose; (2) methods that increase the distance between heart and irradiated fields; (3) new techniques such as intensity modulated radiotherapy and proton therapy. Although researches in dosimetry have showed that cardiac sparing techniques could lower cardiovascular involvement dose and irradiated volume, further validation is needed for curative effect.
|
| Keywords
Radiotherapy
Radiation-induced cardiovascular toxicity
Cardiac sparing technique
|
|
|
|
Issue Date: 14 November 2018
|
|
[1] McGale P, Darby SC, Hall P, et al. Incidence of heart disease
in 35,000 women treated with radiotherapy for breast cancer in
Denmark and Sweden[J]. Radiother oncol, 2011, 100(2): 167-75.
[2] Clarke M, Collins R, Darby S, et al. Effects of radiotherapy and of
differences in the extent of surgery for early breast cancer on local
recurrence and 15-year survival: an overview of the randomised
trials[J]. Lancet, 2005, 366(9503): 2087-106.
[3] Mulrooney DA, Yeazel MW, Kawashima T, et al. Cardiac
outcomes in a cohort of adult survivors of childhood and
adolescent cancer: retrospective analysis of the Childhood Cancer
Survivor Study cohort[J]. BMJ, 2009, 339: b4606.
[4] Stewart JR, Fajardo LF. Radiation-induced heart disease: an
update[J]. Prog Cardiovasc Dis, 1984, 27(3): 173-94.
[5] Fajardo LF, Stewart JR. Capillary injury preceding radiationinduced
myocardial fibrosis[J]. Radiology, 1971, 101(2): 429-33.
[6] Gabriels K, Hoving S, Seemann I, et al. Local heart irradiation of
ApoE(-/-) mice induces microvascular and endocardial damage
and accelerates coronary atherosclerosis[J]. Radioth Oncol, 2012,
105(3): 358-64.
[7] Lee MS, Finch W, Mahmud E. Cardiovascular complications of
radiotherapy[J]. Am J Cardiol, 2013, 112(10): 1688-96.
[8] Darby SC, Ewertz M, McGale P, et al. Risk of Ischemic Heart
Disease in Women after Radiotherapy for Breast Cancer[J]. N
Engl J Med, 2013, 368(11): 987-98.
[9] Harris EE, Correa C, Hwang WT, et al. Late cardiac mortality
and morbidity in early-stage breast cancer patients after breastconservation
treatment[J]. J Clin Oncol, 2006, 24(25): 4100-6.
[10] Maraldo MV, Giusti F, Vogelius IR, et al. Cardiovascular disease
after treatment for Hodgkin’s lymphoma: an analysis of nine
collaborative EORTC-LYSA trials[J]. Lancet Haematol, 2015,
2(11): e492-502.
[11] Cutter DJ, Schaapveld M, Darby SC, et al. Risk of valvular heart
disease after treatment for Hodgkin lymphoma[J]. J Natl Cancer
Inst, 2015, 107(4): pii: djv008.
[12] Fukada J, Shigematsu N, Takeuchi H, et al. Symptomatic
pericardial effusion after chemoradiation therapy in esophageal
cancer patients[J]. Int J Radiat Oncol Biol Phys, 2013, 87(3):
487-93.
[13] Ning MS, Tang L, Gomez DR, et al. Incidence and predictors
of pericardial effusion after chemoradiation therapy for locally
advanced non-small cell lung cancer[J]. Int J Radiat Oncol Biol
Phys, 2017, 99(1): 70-9.
[14] Ogino I, Watanabe S, Iwahashi N, et al. Symptomatic radiationinduced
cardiac disease in long-term survivors of esophageal
cancer[J]. Strahlenther Onkol, 2016, 192(6): 359-67.
[15] Taylor CW, Wang Z, Macaulay E, et al. Exposure of the Heart in
Breast Cancer Radiation Therapy: A Systematic Review of Heart
Doses Published During 2003 to 2013[J]. Int J Radiat Oncol Biol
Phys, 2015, 93(4): 845-53.
[16] Hiatt JR, Evans SB, Price LL, et al. Dose-modeling study
to compare external beam techniques from protocol NSABP
B-39/RTOG 0413 for patients with highly unfavorable cardiac
anatomy[J]. Int J Radiat Oncol Biol Phys, 2006, 65(5): 1368-74.
[17] Appelt AL, Vogelius IR, Bentzen SM. Modern hypofractionation
schedules for tangential whole breast irradiation decrease the
fraction size-corrected dose to the heart[J]. Clin Oncol (R Coll
Radiol), 2013, 25(3): 147-52.
[18] Maraldo MV, Brodin NP, Vogelius IR, et al. Risk of developing
cardiovascular disease after involved node radiotherapy versus
mantle field for Hodgkin lymphoma[J]. Int J Radiat Oncol Biol
Phys, 2012, 83(4): 1232-7.
[19] Joo JH, Kim SS, Ahn SD, et al. Cardiac dose reduction during
tangential breast irradiation using deep inspiration breath hold: a
dose comparison study based on deformable image registration[J].
Radiat Oncol, 2015, 10: 264.
[20] Mohamad O, Shiao J, Zhao B, et al. Deep inspiration breathhold
for left-sided breast cancer patients with unfavorable cardiac
anatomy requiring internal mammary nodal irradiation[J]. Pract
Radiat Oncol, 2017, 7(6): e361-7.
[21] Mulliez T, Van de Velde J, Veldeman L, et al. Deep inspiration
breath hold in the prone position retracts the heart from the breast
and internal mammary lymph node region[J]. Radiother Oncol,
2015, 117(3): 473-6.
[22] Deseyne P, Speleers B, De Neve W, et al. Whole breast and
regional nodal irradiation in prone versus supine position in left
sided breast cancer[J]. Radiat Oncol, 2017, 12(1): 89.
[23] Beckham WA, Popescu CC, Patenaude VV, et al. Is multibeam
IMRT better than standard treatment for patients with left-sided
breast cancer?[J]. Int J Radiat Oncol Biol Phys, 2007, 69(3): 918-24.
[24] Xie X, Ouyang S, Wang H, et al. Dosimetric comparison of leftsided
whole breast irradiation with 3D-CRT, IP-IMRT and hybrid
IMRT[J]. Oncol Rep, 2014, 31(5): 2195-205.
[25] Xu D, Li G, Li H, et al. Comparison of IMRT versus 3D-CRT in
the treatment of esophagus cancer: A systematic review and metaanalysis[
J]. Medicine (Baltimore), 2017, 96(31): e7685.
[26] Lin LL, Vennarini S, Dimofte A, et al. Proton beam versus photon
beam dose to the heart and left anterior descending artery for leftsided
breast cancer[J]. Acta Oncol, 2015, 54(7): 1032-9.
[27] Mast ME, Vredeveld EJ, Credoe HM, et al. Whole breast proton
irradiation for maximal reduction of heart dose in breast cancer
patients[J]. Breast Cancer Res Treat, 2014, 148(1): 33-9.
[28] Wu SZ, Tao LY, Wang JN, et al. Amifostine pretreatment
attenuates myocardial ischemia/reperfusion injury by inhibiting
apoptosis and oxidative stress[J]. Oxid Med Cell Longev, 2017,
2017: 4130824.
[29] Qian L, Cao F, Cui J, et al. The Potential Cardioprotective Effects
of Hydrogen in Irradiated Mice[J]. J Radiat Res, 2010, 51(6):
741-7.
[30] Zhang ZY, Li Y, Li R, et al. Tetrahydrobiopterin Protects against
Radiation-induced Growth Inhibition in H9c2 Cardiomyocytes[J].
Chin Med J (Engl), 2016, 129(22): 2733-40.
[31] Fan Z, Han Y, Ye Y, et al. l-carnitine preserves cardiac function
by activating p38 MAPK/Nrf2 signalling in hearts exposed to
irradiation[J]. Eur J Pharmacol, 2017, 804: 7-12. |
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
| |
Shared |
|
|
|
|
| |
Discussed |
|
|
|
|
