模板辅助<sup>192</sup>Ir源大分割立体近距离放射消融术治疗周围型肺癌的剂量学研究

高琴; 庞皓文; 石翔翔; 任培蓉; 林盛

doi:10.3971/j.issn.1000-8578.2021.20.1051

模板辅助¹⁹²Ir源大分割立体近距离放射消融术治疗周围型肺癌的剂量学研究

Dosimetric Analysis of Template-assisted ¹⁹²Ir-source Hypofractionated Stereotactic Ablative Brachytherapy for Peripheral Lung Cancer

摘要

摘要:
目的探讨模板辅助¹⁹²Ir源大分割立体近距离放射消融术（SABT）治疗周围型肺癌的剂量。
方法回顾性分析28例接受模板辅助¹⁹²Ir源大分割SABT治疗周围型肺癌患者的靶区与危及器官剂量，制作虚拟立体定向放射治疗（SBRT）计划与SABT计划进行剂量参数对比。
结果 SABT计划肿瘤靶区D_mean和V₁₅₀明显高于SBRT计划（均P < 0.01）；危及器官（organ at risk, OAR）肺D_1000cm³和D_1500cm³差异无统计学意义（均P > 0.05），SABT剩余剂量参数均明显低于SBRT计划（均P < 0.01）。
结论在周围型肺癌治疗中模板辅助¹⁹²Ir源大分割SABT确保靶区高剂量同时降低危及器官剂量。

Abstract:
Objective To explore the dose of template-assisted ¹⁹²Ir source hypofractionated stereotactic brachytherapy (SABT) for peripheral lung cancer.
Methods We retrospectively analyzed the dose parameters of GTV and OARs of 28 peripheral lung cancer patients treated with template-assisted ¹⁹²Ir-source hypofractionated SABT, and compared the dose parameters between SABT with virtual SBRT.
Results The D_mean and V₁₅₀ for the GTV in the SABT plan were significantly higher than those in the SBRT plan (all P < 0.01). For OARs, all dosimetric parameters in the SABT plan were significantly lower than those in the SBRT plan (all P < 0.01), except for the D_1000cm³ and D_1500cm³ for the lung (P > 0.05).
Conclusion Template-assisted ¹⁹²Ir source hypofractionated SABT ensures high dose in the gross tumor volume and reduces the dose in organs at risk in the treatment of peripheral lung cancer.

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模板辅助192Ir源大分割立体近距离放射消融术治疗周围型肺癌的剂量学研究

Dosimetric Analysis of Template-assisted 192Ir-source Hypofractionated Stereotactic Ablative Brachytherapy for Peripheral Lung Cancer

模板辅助¹⁹²Ir源大分割立体近距离放射消融术治疗周围型肺癌的剂量学研究

Dosimetric Analysis of Template-assisted ¹⁹²Ir-source Hypofractionated Stereotactic Ablative Brachytherapy for Peripheral Lung Cancer