Abstract: Objective 　According to the diagnosis of classical supercarcinoma and the criterion of the WHO pathology of new classify of tumours in 2000 years, which is high grade int raepithelial neoplasia ( HIN), to investigate prevalence condition for multiplecarcinoma and HIN in the area of high incidence of esopha2 geal carcinoma. Methods 　Two thousand and thirteen persons with 40～69 age and through endoscopic examination were enrolled in cohort study, depending on the criterion of the WHO pathology of new clas2 sify of tumours, severe dysplasia, carcinoma2in2situ for esophageal sequmous cell and severe dysplasia, in2 t ramucosal cancer for cardia adeno2epithelia cell were classiified as high2grade int raepithelia neoplasia ( HIN) . For pathology at the same time were HIN in esophagus with cardia as multiple2HIN diagnosis, still Warren standard was adopted for esophagus with cardia multiplecarcinamo ( ECM) . Results 　Preva2 lence rate was 0. 01 % for ECM, it occupied 2. 2 % on total detecting carcinoma2in2situ, int ramucosal canc2 er and early invasive carcinoma, multiple HIN was 0. 2 %, that account for 3. 3 % in all HIN. Conclusion Forty～Sixty2five years old crowd in Ci2county, prevalence rate were relatively higher for ECM and multi2 ple2HIN.