血清血管内皮因子浓度检测在恶性肿瘤预后监测中的意义

Significance of clinical determination of serum VEGF in prognosis of malignant tumor

摘要: 目的　研究人血管内皮因子的浓度与恶性肿瘤之间的关系。方法　用自制备的VEGF多克隆抗体对 342例肿瘤患者与正常人群血清VEGF浓度进行检测。结果　恶性肿瘤血清VEGF水平高于正常人 (P <0 .0 1), 另外对 12 2例非小细胞肺癌患者血清VEGF水平进行了检测和动态观察, 结果显示血清VEGF浓度大于 35 0 μg/l的患者两年生存率低于血清浓度小于 35 0 μg/l的患者 (P <0 .0 1)。结论　VEGF是重要的肿瘤血管生成因子, 其血清浓度的检测可作为评价肿瘤预后的一项有价值的指标, 并为抗肿瘤血管治疗提供一定参考

Abstract: Objective To study the relationship between Human VEGF level and malignant tumor. Methods We determined the serum VEGF with self-made VEGF monoclonal antibody in 342 patients of malignant tumor and normal persons. Results The serum VEGF level in the patients with malignant tumor were higher than that in normal person( P <0.01). And we determined the serum VEGF level and did dynamic observation in 122 patients with non-small-cell lung cancer. The result showed that the two-year survival rate in ...