胶质瘤的CT灌注成像与微血管密度的相关性

黄劲柏; 任伯绪; 雷红卫; 蔡新宇; 熊浩; 陈昌毅

doi:10.3971/j.issn.1000-8578.2011.01.022

胶质瘤的CT灌注成像与微血管密度的相关性

Correlations between CT Perfusion Imaging and Microvessel Density in Gliomas

摘要

摘要: 目的探讨胶质瘤CT灌注成像参数相对脑血容量（rCBV）与肿瘤微血管密度（MVD）的相关性，以及对胶质瘤分级的价值。方法 30例胶质瘤患者,低级别组11例,高级别组19例。常规CT扫描的基础上行CT灌注成像检查。测量肿瘤实质部分CBV的绝对值和相对值,并对两组进行比较。术后病理切片行SP 法免疫组织化学染色，检测MVD水平，并分析rCBV与MVD的相关性。结果经Spearman相关分析，rCBV与MVD间呈显著正相关（r=0.562，P<0.05）。低级别与高级别胶质瘤rCBV的均值分别为（2.31±0.28）、（4.69±1.65），两组间比较差异有统计学意义。结论 rCBV与MVD间存在良好的相关性，对胶质瘤术前分级具有临床实用价值。

Abstract: Abstract:Objective To discuss the correlations between relative cerebral blood volume (rCBV) value of CT perfusion imaging and microvessel density(MVD), and to explore the value of rCBV for preoperative grading of gliomas．Methods Thirty cases of glioma patients (11 low grade and 19 high grade astrocytomas) underwent conventional CT and CT perfusion imaging examination before operation. The absolute and relative value of CBV were measured in the parenchyma part of glioma and were processed statistically．The mean MVD of the lesions were measured immunohistochemically in all the histologie specimens. The relationship between rCBV and MVD were analyzed. Results The rCBV value had significantly positive（r=0.562，P<0.05） correlation with MVD. The mean values of rCBV in low and high grade gliomas were （2.31±0.28） and （4.69±1.65） respectively．The value of rCBV between the two groups showed significant differences. Conclusion The value of rCBV is in good agreement with MVD, and is valuable for preoperative grading of gliomas in clinical procedures．

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