612例鼻咽癌放射治疗预后因素分析
Prognostic Factors of 612 Patients with Nasopharyngeal Carcinoma Treated with Radiotherapy
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摘要: 目的 1973年1月至1987年12月我院共放射治疗鼻咽癌612例,本文对其 结果 及影响预后的因素予以分析。全组总的5年生存率42．2％。性别、年龄对预后无明显影响,病期、原发肿瘤超胜,预淋巴结转移、颅神经受损和照射剂量是主要的预后因素。随着病期变晚,5年生存率逐渐下降,Ⅰ、Ⅱ期的5年生存率明显高于Ⅲ、Ⅳ期（P＜0．01）。肿瘤局限于鼻咽腔者的预后明显好于超腔者（P＜0．01）。前后组颅神经同时受累预后最差。预淋巴结转移的大小、单双侧、部位、活动或固定对预后有不同的影响。放疗剂量应以65－75Gy／6．5－7．5周为宜。本组资料证明,鼻咽癌放疗失败的主要原因是远处转移与局部复发。Abstract: Objective analysis of 612 patients with nasopharyngeal carcinoma(NPC)treated by radiotherapy from January,1973 to December,1987 was done.The overall 5-year survival rate was 42.2%.Analysis showed that tumor stage,extra-cavitary extension,cervical node metastasis,cranial nerve involvement and dosage were the main signifi-cant prognostic factors.Gradual decrease of 5-year survival rate was seen from stage Ⅰ to Ⅳ,The 5-year survival rate was higher in patients with the tumor limited in nasopharynx than those with tumor extending out of nasopharynx(P＜0.01).The invasion of both anterior and posterior cranial never groups was the poorest.The size,region(ipsilateral of bilateral and upper or lower neck)and movability of the metastatic nodes could influence therapeutic results on NPC.The radiation dose ranged from 65-75Gy/6.5-7.5W.Distant metastasis and local recurrence were the main causes of treatment failure.
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Key words:
- nasopharyngeal carcinoma /
- radiotherapy /
- prognosis
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1 谷铣之,殷蔚伯,刘泰福.等主编.肿瘤放射治疗学.北京医科大学中国协和医科大学联合出版社,1993:504 2 Perez CA. Nasopharynx. In: Perez CA, Brady LR(eds).Principles and practice of radiation oncology.2nd ed. Philadelphia:JB Lippincott Co, 1992,1495一1507 3 Lee.AWM, Poon YF, FaoW,et al. Retrospective analysis of 5037 patients with nasopharygeal carcinoma treated during 1976一1985: overall survival and patterns of failure. lot. J. Radial. Onwl. Bid.Phys,1992,23:261 4 胡心传,王者香,王骏业,等.1101例鼻咽癌放射治疗的远期疗效及影响疗效因素.中国肿瘤临床,1989,16:23 5 魏国仓,陆士琪,张永禄,等.鼻咽癌放疗结果与预后相关因素.中国肿瘤临床,1996,23:498 6 胡国清,胡长耀,陈元.顺铂和放射治疗联合应用治疗晚期鼻咽癌的临床研究.中华放射肿瘤学杂志,1994.3:244
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