人胃癌及癌前病变中NF-KappaB和c-myc蛋白的表达与意义
Expression of NF-KappaB and c-myc protein in gastric carcinogenesis
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摘要: 目的 探讨胃癌及癌前病变中NF κB亚单位 p6 5蛋白和c myc蛋白的表达及相互关系。 方法 用免疫组化法检测 4 1例胃癌及 2 5例相应非癌组织的 p6 5和c myc蛋白。 结果 (1)正常胃粘膜→肠型化生→不典型增生→胃癌中, 两种蛋白的阳性表达率渐次升高, 且增生组、胃癌组与正常组相比差异分别有显著性, 肠化与胃癌组间也有显著性差异 (P <0 .0 5 ) ;(2 )胃癌中, 两种蛋白的表达在低未分化、进展期、有淋巴结转移和浸润至浆膜层的肿瘤中显著增高 (P <0 .0 5 ) ;(3)肠化、增生和胃癌中, 两者的表达分别具有中到强正相关 (rs=0 .6 12～ 0 .84 5, P <0 .0 1)。结论 NF κBp6 5蛋白活性表达的增加是胃癌发生中的早期事件, c myc基因产物可能作为其效应子, 在胃癌的发生发展中发挥重要作用Abstract: Objective To investigate the variant expression of NF-κBp65 and c-myc protein and their relationships in gastric carcinogenesis. Methods A total of 41 primary gastric tumors and 24 corresponding noncancer specimens were examined. Expression of activated NF-κB and c-myc protein were determinded by immunohistochemistry. Results (1) In normal mucosa-intestinal metaplasia-dysplasia-neoplasia, p65 expression were 0, 34.78%, 53.33%, 60.98%,while c-myc protein were 0, 30.43%, 53.33%, 58.54%, respectivel...
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