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血清25-羟基维生素D3及钙水平与胃癌的关系[J]. 肿瘤防治研究, 2015, 42(04): 369-372. DOI: 10.3971/j.issn.1000-8578.2015.04.011
引用本文: 血清25-羟基维生素D3及钙水平与胃癌的关系[J]. 肿瘤防治研究, 2015, 42(04): 369-372. DOI: 10.3971/j.issn.1000-8578.2015.04.011
Relationship Between Serum 25-(OH) D3, Ca2+ and Gastric Carcinoma[J]. Cancer Research on Prevention and Treatment, 2015, 42(04): 369-372. DOI: 10.3971/j.issn.1000-8578.2015.04.011
Citation: Relationship Between Serum 25-(OH) D3, Ca2+ and Gastric Carcinoma[J]. Cancer Research on Prevention and Treatment, 2015, 42(04): 369-372. DOI: 10.3971/j.issn.1000-8578.2015.04.011

血清25-羟基维生素D3及钙水平与胃癌的关系

Relationship Between Serum 25-(OH) D3, Ca2+ and Gastric Carcinoma

  • 摘要: 目的 探讨血清25-(OH)D3及钙(Ca2+)水平与胃癌的关系。方法 选取郑州大学第一附属医院经病理确诊为慢性浅表性胃炎(对照组)患者63例,胃癌(病例组)患者118例。采用酶联免疫吸附法(ELISA)测定入选对象血清25-(OH)D3水平,离子选择性电极(ISE)电位法测定入选对象血清Ca2+水平。结果 病例组外周血25-(OH)D3水平显著低于对照组(t=15.07,P=0.000),而其血清Ca水平与对照组比较,差异无统计学意义(t=1.109,P=0.269),病例组内血清25-(OH)D3水平与Ca2+之间呈正相关(r=0.706,P=0.000)。外周血25-(OH)D3水平在不同细胞分化程度的胃癌组间差异有统计学意义(F=3.356,P=0.038)。胃癌经手术治疗后,术后外周血25-(OH) D3水平高于术前,差异有统计学意义(t=−8.017,P=0.000)。但胃癌淋巴结转移与无淋巴结转移组间血清25-(OH)D3水平无统计学意义(t=0.061,P=0.952)。结论 血清 25-(OH)D3水平可能与胃癌的发生、发展相关,手术治疗后其水平明显升高,可用于监测胃癌患者病情变化、预测预后。

     

    Abstract: Objective To investigate the association between serum 25-(OH) D3, Ca2+ and gastric cancer. Methods A total of 63 patients pathologically diagnosed as chronic superficial gastritis(Control group) and a total of 118 patients pathologically diagnosed as gastric cancer(Case group) were selected from The First Affiliated Hospital of Zhengzhou University. The level of serum 25-(OH) D3 was measured by ELISA, and the level of Ca2+ was measured by ISE potential method. Results The level of 25-(OH) D3 of case group was significantly lower than that of control group(t=15.07, P=0.000), but no significance was found in comparison of Ca2+ between them(t=1.109, P=0.269). There was a positive correlation between serum 25-(OH) D3 concentration and Ca2+ in case group(r=0.706, P=0.000). The difference of 25-(OH) D3 levels among case groups with different cell differentiation degrees was statistically significant(F=3.356, P=0.038). When patients had taken gastric operation, the serum level of 25-(OH) D3 was higher in postoperative group than that in preoperative group(t=−8.017, P=0.000). However, no statistical significance was found between positive lymph node metastasis group and negative lymph node metastasis group (t=0.061, P=0.952). Conclusion The level of serum 25-(OH) D3 may be associated with the occurrence and development of gastric cancer, and it is significantly increased after surgery; therefore, the serum 25-(OH) D3 could be used to monitor gastric carcinoma patients' conditions, prediction and prognosis.

     

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