A Randomized Trial of NP Therapy Plus Radiotherapy Versus FLP Therapy Plus Radiotherapy in the Treatment of Esophagus

Objective 　To compare the response rate and the side effects of the regimen NPR (NVB + DDP+ radiotherapy) with the regimen FLPR ( FLP (5-Fu/ CF + DDP) + radiotherapy) in the treatment of eophagus. Methods 　A total of 63 cases with esophagus entered this trial. The patient s were randomly divided into two groups, group A with 31 cases and group B with 32 cases. The patient s in group A received the NPR regimen ( i. e. NP therapy for two cycles and then palliative radiotherapy with about 6500cGy), and the patients in group B received the FLPR regimen ( FLP therapy for two cycles and then palliative radiotherapy with about 6500cGy) . Results 　①The total response rate of the NPR regimen was 83. 9 %, the median survival time (MST) was 14. 7 months, the one-year survival rate ( YSR) was 76. 0 %, but the total response rate of FLPR regimen was 71. 9 %, MST was 12. 3 months, YSR 69. 0 %, and there was no significant difference between these two regimens ( P > 0. 05) ; ②The main side effect of these two regimens was bone marrow depression, and the grade Ⅲ～ Ⅳ leucopenia was 16. 1 % in group A, and 6. 3 % in group B ( P > 0. 05) . Conclusion 　The total response rate and the one-year survival rate of the NPR regimen were higher than the FLPR regimen. Although there was no significant difference between these two regimens, the patient s treated with the NPR regimens has higher CR rate compared with the FL PR regimen, and can tolerate the poisonous and side effects.