Clinical Value of Radical Trachelectomy in Patients with Early Cervical Cancer:A System Review

Objective To systematically evaluate the safety and feasibility of radical trachelectomy in patients with early-stage cervical cancer who desired to maintain fertility. Methods Electronic databases including Pubmed，EMBASE，Cochrane Library and Chinese full-text database were systematically searched for all relevant published studies on radical trachelectomy(RT)and(or) radical hysterectomy(RH) in patients with early stage of cervical cancer.Meta-analysis was performed on controlled trials of RT and RH,and homogeneous merger analysis was only performed on non-controlled of RT.The primary outcome measures were survival rate and pregnancy rate. Results A total of four controlled trials of RT and RH were included in this meta-analysis and 17 non-controlled trials of RT also met the inclusion criteria.No significant differences were found.The total pregnancy rate was 47% after radical trachelectomy in patients with early-stage cervical cancer. Conclusion Radical trachelectomy appears safe when performed by sufficient surgery.It can satisfy the patients'needs to preserve the fertility.The conclusion is needed to be further assessed by rigorously designed,random and double-blind,controlled clinical trials.