Abstract: Cancer-related depression (CRD) is a common pathological depression in the diagnosis and treatment of malignant tumors, and is one of the important factors affecting the progression and treatment of tumor diseases. Abdominal vibration therapy is developed from Professor Zang 's loose vibration method. It is a set of techniques that mainly operate by vibrating Shenque point, dredging meridians, rubbing abdomen, pushing abdomen and holding abdomen. This therapy has unique advantages in the treatment of emotional diseases, possibly because it can stimulate the abdomen, achieve the effect of tonifying the spleen and stomach, regulating the gut organs, regulating the qi mechanism, and regulating the vitality. Based on the structure of the "brain-gut" axis, it regulates the inflammatory response, and then realizes the purpose of intervening in CRD.