高级搜索

软骨肉瘤的相关分子机制研究进展

冯和林, 赵亚恒, 郑丽华, 冯建刚

冯和林, 赵亚恒, 郑丽华, 冯建刚. 软骨肉瘤的相关分子机制研究进展[J]. 肿瘤防治研究, 2014, 41(04): 416-420. DOI: 10.3971/j.issn.1000-8578.2014.04.030
引用本文: 冯和林, 赵亚恒, 郑丽华, 冯建刚. 软骨肉瘤的相关分子机制研究进展[J]. 肿瘤防治研究, 2014, 41(04): 416-420. DOI: 10.3971/j.issn.1000-8578.2014.04.030
FENG Helin, ZHAO Yaheng, ZHENG Lihua, FENG Jiangang. Advances in Research on Related Molecular Mechanisms of Chondrosarcoma[J]. Cancer Research on Prevention and Treatment, 2014, 41(04): 416-420. DOI: 10.3971/j.issn.1000-8578.2014.04.030
Citation: FENG Helin, ZHAO Yaheng, ZHENG Lihua, FENG Jiangang. Advances in Research on Related Molecular Mechanisms of Chondrosarcoma[J]. Cancer Research on Prevention and Treatment, 2014, 41(04): 416-420. DOI: 10.3971/j.issn.1000-8578.2014.04.030

软骨肉瘤的相关分子机制研究进展

基金项目: 河北省科技厅支撑课题基金资助项目(11276156)
详细信息
    作者简介:

    冯和林(1978-),男,硕士,主治医师,主要从事骨与软组织肿瘤研究与诊治工作

    赵亚恒(1987-),男,硕士在读,主要从事骨与软组织肿瘤的基础与临床研究(*:并列第一作者)

    通信作者:

    冯建刚,E-mail:hbydsy@yahoo.cn

  • 中图分类号: R738.1

Advances in Research on Related Molecular Mechanisms of Chondrosarcoma

  • 摘要: 软骨肉瘤是骨组织第二大常见恶性肿瘤,约占恶性骨肿瘤的20%,它具有局部侵袭性和远处转移性。各种肿瘤抑癌基因、致癌基因、细胞因子和错综复杂的信号级联放大途径都和软骨肉瘤的发病相关,并且同源染色体丢失、核型改变也关系到软骨恶变。CCN6、WISP-1、HMGB-1、TNF-α、IL-6、IGF和COXs的异常表达能够通过激活一系列的信号转导途径及分子来促进软骨肉瘤细胞的转移。近年众多研究表明上述因素和软骨肉瘤的发病机制有关。本文将对这些因素在软骨肉瘤的发生发展方面的作用作一简要综述。
    Abstract: Chondrosarcoma is the second most common malignant bone tumor with a potent capacity to invade locally and cause distant metastasis and accounts for approximately 20% of malignant bone lesions. Various tumor suppressor genes, oncogenes, cytokines, and intricate networks of signaling cascades have been associated with chondrosarcoma. The malignant cartilage-producing is associate with the loss of chromosomes or karyotypic alterations. The abnormal expression of CCN6, WISP-1, HMGB-1, TNF-α, IL-6, IGF and COXs have increased the migration of human chondrosarcoma cells by activating a series of signal transduction pathways and molecules. In recent years, accumulating studies have suggested their association with the pathogenesis of chondrosarcoma. This article reviews the role of these factors in the genesis and development of human chondrosarcoma.
  • [1] Koch BB, Karnell LH, Hoffman HT, et al. National Cancer database report on chondrosarcoma of the head and neck[J]. Head Neck, 2000, 22(4):408-25.
    [2] Sammartino G, Marenzi G, Howard CM, et al. Chondrosarcoma of the jaw: a closer look at its management[J]. J Oral Maxillofac Surg, 20 08, 66(11):2349-55.
    [3] Yuan J, Dutton CM, Scully SP. RNAi mediated MMP-1 silencing inhibits human chondrosarcoma invasion[J]. J Orthop Res,2005,23(6):1467-74.
    [4] Schrage YM, Lam S, Jochemsen SG, et al. Cenral chondrosarcoma progression is associated with pRb pathway alterations: CDK4 downregulation and p16 overexpression inhibit cell growth in vitro[J]. J Cell Mol Med,2009,13(9A):2843-52.
    [5] McDermott KM, Zhang J, Holst CR, et al. p16(INK4a) prevents centrosome dysfunction and genomic instability in primary cells[J]. PLoS Biol,2006,4(3):e51.
    [6] Silkworth WT, Nardi IK, Scholl LM, et al. Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells[J]. PLoS One,2009,4(8):e6564.
    [7] Ganem NJ, Godinho SA, Pellman D. A mechanism linking extra centrosomes to chromosomal instability[J]. Nature,2009,460(7252): 27 8-82.
    [8] Olsson L, Paulsson K, Bovée JV, et al. Clonal evolution through loss of chromosomes and subsequent polyploidization in chondrosarcoma[J]. PLoS One, 2011, 6(9): e24977.
    [9] Fong YC, Lin CY, Su YC, et al. CCN6 enhances ICAM-1 expression and cell motility in human chondrosarcoma cells[J]. J Cell Physiol,2012,227(1):223-32.
    [10] Tan TW, Lai CH, Huang CY, et al. CTGF enhances migration and MMP-13 up-regulation via alphavbeta3 integrin, FAK, ERK, and NF-kappaB-dependent pathway in human chondrosarcoma cells[J]. J Cell Biochem,2009,107(2):345-56.
    [11] Qin HM, Han HF, Sha GZ, et al. Relationship between Caspase-3 and PTHrp, Sex9 genes respectively in chondrosarcoma cell line[J]. Zhonghua Zhong Liu Fang Zhi Za Zhi,2008,15(22):1717-20. [秦宏敏, 韩会峰, 沙广钊, 等. 软骨肉瘤细胞Caspase-3表达 及其与相关基因相互作用的研究[J]. 中华肿瘤防治杂志, 20 08,15(22):1717-20.]
    [12] Holbourn KP, Acharya KR, Perbal B. The CCN family of proteins: structure-function relationships[J]. Trends Biochem Sci,2008,33(10):461-73.
    [13] Hou CH, Chiang YC, Fong YC, et al. WISP-1 increases MMP-2 expression and cell motility in human chondrosarcoma cells[J]. Biochem Pharmacol,2011,81(11):1286-95.
    [14] Tang CH, Keng YT, Liu JF. HMGB-1 induces cell motility and α5β1 integrin expression in human chondrosarcoma cells[J]. Cancer Lett,2012,322(1):98-106.
    [15] Hou CH, Yang RS, Hou SM, et al. TNF-α increases αvβ3 integrin expression and migration in human chondrosarcoma cells[J]. J Cell Physiol, 2011, 226(3): 792-9.
    [16] Sun WY, Pitson SM, Bonder CS. Tumor necrosis factor-induced neutrophil adhesion occurs via sphingosine kinase-1-dependent activation of endothelial {alpha}5{beta}1 integrin[J]. Am J Pathol, 20 10,177(1):436-46.
    [17] Tang CH, Chen CF, Chen WM, et al. IL-6 increases MMP-13 expression and motility in human chondrosarcoma cells[J]. J Biol Chem,2011,286(13):11056-66.
    [18] Bruchim I, Attias Z, Werner H. Targeting the IGF1 axis in cancer proliferation[J]. Expert Opin Ther Targets,2009,13(10):1179-92.
    [19] Gualberto A, Karp DD. Development of the monoclonal antibody figitumumab, targeting the insulin-like growth factor-1 receptor, for the treatment of patients with non-small-cell lung cancer[J]. Clin Lung Cancer,2009,10(4):273-80.
    [20] Wu CM, Li TM, Hsu SF, et al. IGF-I Enhances α5β1 integrin expression and cell motility in human chondrosarcoma cells[J]. J Cell Physiol,2011,226(12):3270-7.
    [21] Bibollet-Bahena O, Almazan G. IGF-1-stimulated protein synthesis in oligodendrocyte progenitors requires PI3K/mTOR/Akt and MEK/ERK pathways[J]. J Neurochem,2009,109(5):1440-51.
    [22] Huang CY, Fong YC, Lee CY, et al. CCL5 increases lung cancer migration via PI3K, Akt and NF-kappaB pathways[J]. Biochem Pharmacol,2009,77(5):794-803.
    [23] Qureshi HY, Ahmad R, Sylvester J, et al. Requirement of phosphatidylinositol3-kinase/Akt signaling pathway for regulation of tissue inhibitor of metalloproteinases-3 gene expression by TGFbeta in human chondrocytes[J]. Cell Signal, 2007, 19(8):1643-51.
    [24] Luo WR, Chen XY. Research advance of the relationship between cyclooxygenase-2 and tumor[J]. Zhong Liu Fang Zhi Yan Jiu, 2006, 33 (1):62-4. [罗伟仁, 陈小毅. 环氧化酶-2与肿瘤的关系[J]. 肿瘤 防治研究,2006,33(1):62-4.]
    [25] Liu JF, Fong YC, Chang CS, et al. Cyclooxygenase-2 enhances alpha2beta1 integrin expression and cell migration via EP1 dependent signaling pathway in human chondrosarcoma cells[J]. Mol Cancer,2010,9:43.
    [26] Chiu YC, Shieh DC, Tong KM, et al. Involvement of AdipoR receptor in adiponectin-induced motility and alpha2beta1 integrin upregulation in human chondrosarcoma cells[J]. Carcinogenesis 20 09,30(10):1651-9.
计量
  • 文章访问数:  1969
  • HTML全文浏览量:  530
  • PDF下载量:  916
  • 被引次数: 0
出版历程
  • 收稿日期:  2013-07-23
  • 修回日期:  2014-01-23
  • 刊出日期:  2014-04-24

目录

    Corresponding author: FENG Jiangang, hbydsy@yahoo.cn

    1. On this Site
    2. On Google Scholar
    3. On PubMed

    /

    返回文章
    返回
    x 关闭 永久关闭