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染色体1q21扩增对硼替佐米或沙利度胺治疗初治多发性骨髓瘤疗效的影响

曾添美, 叶飞, 张春阳, 傅卫军, 李璐, 周帆, 侯健

曾添美, 叶飞, 张春阳, 傅卫军, 李璐, 周帆, 侯健. 染色体1q21扩增对硼替佐米或沙利度胺治疗初治多发性骨髓瘤疗效的影响[J]. 肿瘤防治研究, 2013, 40(06): 521-524. DOI: 10.3971/j.issn.1000-8578.2013.06.004
引用本文: 曾添美, 叶飞, 张春阳, 傅卫军, 李璐, 周帆, 侯健. 染色体1q21扩增对硼替佐米或沙利度胺治疗初治多发性骨髓瘤疗效的影响[J]. 肿瘤防治研究, 2013, 40(06): 521-524. DOI: 10.3971/j.issn.1000-8578.2013.06.004
ZENG Tianmei, YE Fei, ZHANG Chunyang, FU Weijun, LI Lu, ZHOU Fan, HOU Jian. Impact of 1q21 Amplification on Prognosis of Multiple Myeloma Treated with Bortezomib or Thalidomide[J]. Cancer Research on Prevention and Treatment, 2013, 40(06): 521-524. DOI: 10.3971/j.issn.1000-8578.2013.06.004
Citation: ZENG Tianmei, YE Fei, ZHANG Chunyang, FU Weijun, LI Lu, ZHOU Fan, HOU Jian. Impact of 1q21 Amplification on Prognosis of Multiple Myeloma Treated with Bortezomib or Thalidomide[J]. Cancer Research on Prevention and Treatment, 2013, 40(06): 521-524. DOI: 10.3971/j.issn.1000-8578.2013.06.004

染色体1q21扩增对硼替佐米或沙利度胺治疗初治多发性骨髓瘤疗效的影响

详细信息
    作者简介:

    曾添美(1983-),女,本科,住院医师,主要从事临床血液病学工作

  • 中图分类号: R733.3

Impact of 1q21 Amplification on Prognosis of Multiple Myeloma Treated with Bortezomib or Thalidomide

  • 摘要: 目的 探讨1q21扩增与接受硼替佐米或沙利度胺治疗的初治骨髓瘤患者疗效的关系。 方法 应用FISH技术对108名接受硼替佐米和(或)沙利度胺治疗的初治骨髓瘤患者进行1q21扩增的检测,并分析其与患者临床特征及疗效间的关系。 结果 完成检测的108例患者中,有29例(26.9%)1q21扩增阳性。伴有1q21扩增的患者与不伴1q21扩增的患者中位年龄分别为62岁与58岁 (P=0.029),血红蛋白均值分别为81.39 g/L与97.58 g/L(P=0.002),其余临床特征如肌酐、血钙、 白蛋白、β2微球蛋白及骨髓浆细胞比例两组间差异均无统计学意义。伴有1q21扩增的患者比不伴有1q21扩增的患者合并IgH易位及13q缺失的比例更高(79.3% vs. 48.1%,P=0.004和58.6% vs. 31.6%,P=0.011)。可评估疗效的95例患者中,总有效率为73.7%(70/95),伴1q21扩增患者有效率低于不伴1q21扩增患者(50% vs. 80.8%,P=0.007)。 剔除12例硼替佐米与沙利度胺联合治疗的患者,按治疗方案不同将剩余83例分为硼替佐米组和沙利度胺组,结果显示硼替佐米组伴有1q21扩增患者与不伴有1q21扩增患者治疗有效率差异无统计学意义(70% vs. 80%, P=0.789),而沙利度胺组伴有1q21扩增患者治疗有效率较不伴有1q21扩增患者差(20% vs. 78.3%, P=0.005)。多因素分析显示纳入因素中仅1q21扩增是疗效的独立影响因素,其优势比(OR值)=0.231(95%CI:0.078~0.684,P=0.008)。 结论 1q21扩增是影响多发性骨髓瘤预后的重要因素,伴1q21扩增的患者接受沙利度胺治疗疗效较不伴1q21扩增患者差,但接受硼替佐米治疗疗效与未扩增者无差异。
    Abstract: Objective To analyze the correlation between the 1q21 amplification and the treatment response in patients with multiple myeloma treated with Bortezomib and/or Thalidomide. Methods Fluorescence in situ hybridization (FISH) was used to detect the 1q21 amplification in patients treated with Bortezomib and/or Thalidomide. The clinical characteristics and treatment response werealso analyzed. Results Results 1q21amplification was discovered in 29 of 108 patients (26.9%). The patients with 1q21 amplification had a higher median age and lower HB concentration than those without 1q21 amplification (62y vs. 58y, P=0.029and81.39 g/L vs. 97.58g/L, P=0.002 ). Other clinical characteristics such as SCr, Ca2+, ALB, β2 microglobulin, plasma cell proportion seemed to have no correlation with 1q21 amplification. The patients with 1q21 amplification had a higher rate of IgH translocation and 13q deletion (79.3%vs. 48.1%,P=0.004 and 58.6%vs. 31.6%,P=0.011, respectively). Thetreatment response was evaluable in 95 patients. The overall response rate (ORR) was 73.7% (70/95).Twelve patients treated with both Bortezomib and Thalidomide were excluded and the remained83 patients were divided into two groups(Bortezomib-based and Thalidomide-based). Response rate was not significant difference between patients with and without 1q21 amplification in Bortezomib-based group, but patients with 1q21 amplification had a higher response rate than those without 1q21 amplification in Thalidomide-based group (70% vs. 80%, P=0.789 and 20% vs. 78.3%P=0.005). Multivariate analysis showed 1q21 amplification was an independent prognostic predictor,OR(Odds Ratio)=0.231(95% CI:0.078-0.684,P=0.008). Conclusion 1q21 amplification was a vital predictor of prognosisaspatients with 1q21 amplification had a lower response rate when treated with Thalidomide ratherthan Bortezomib.
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出版历程
  • 收稿日期:  2013-01-15
  • 修回日期:  2013-03-11
  • 刊出日期:  2013-06-24

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    HOU Jian

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    2. On Google Scholar
    3. On PubMed

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