Cancer Research on Prevention and Treatment    2022, Vol. 49 Issue (09) : 913-922     DOI: 10.3971/j.issn.1000-8578.2022.22.0012
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Traditional Chinese Medicine Combined with Chemotherapy in Prevention and Treatment of Recurrence and Metastasis of Locally Advanced Gastric Cancer After Radical Resection: A Meta-analysis
WANG Yue1, ZHAO Weizhe1, LI Xiaojie1, NAN Mengdie1, XIE Meiwen1, LI Peijin1, HOU Li2
1. Graduate School of Beijing University of Chinese Medicine, Beijing 100029, China; 2. Hematology Oncology Department, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
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Abstract Objective To explore the efficacy and safety of traditional Chinese medicine(TCM) combined with chemotherapy in the prevention and treatment of postoperative recurrence and metastasis of locally advanced gastric cancer (LAGC) by meta-analysis. Moreover, we evaluated the efficacy of TCM on the quality of life, immune indexes, and toxic and side effects during adjuvant chemotherapy. Methods The CNKI, Wanfang, PubMed, and other databases were searched by computer. Randomized controlled trials (RCTs) were searched. After literature screening and data extraction, Review Manager 5.3 software provided by Cochrane was used for meta-analysis. Results A total of 18 RCTs were included. Compared with chemotherapy alone, TCM combined with chemotherapy could improve the KPS score and CD3+ and CD4+/CD8+ index levels. The incidence rates of postoperative leucopenia, hemoglobin reduction, thrombocytopenia, nausea and vomiting, diarrhea, and neurotoxicity were reduced. In terms of postoperative QLQ-C30 score, abnormal liver function, and abnormal renal function, the incidence of TCM combined chemotherapy was similar to that of chemotherapy alone, with no statistical difference. Compared with chemotherapy alone, TCM combined chemotherapy could reduce the 1-, 2-, 3-, and 5-year cumulative recurrence and metastasis rates and prolong the disease-free survival time. Conclusion Compared with chemotherapy alone in adjuvant chemotherapy, TCM combined chemotherapy could improve the immune level and KPS score of LACC patients after surgery, reduce the incidence of adverse reactions, as well as reduce the recurrence and metastasis rate of LAGC after surgery and DFS could be improved.
Keywords Locally advanced gastric cancer      Radical gastrectomy      Recurrence and metastasis      Traditional Chinese medicine      Meta-analysis     
ZTFLH:  R735.2  
Fund:Capital Health Development Scientific Research Project (No. 2020-2-4193); Beijing Municipal Science and Technology Project (No. D161100005116004)
Issue Date: 15 September 2022
 Cite this article:   
WANG Yue,ZHAO Weizhe,LI Xiaojie, et al. Traditional Chinese Medicine Combined with Chemotherapy in Prevention and Treatment of Recurrence and Metastasis of Locally Advanced Gastric Cancer After Radical Resection: A Meta-analysis[J]. Cancer Research on Prevention and Treatment, 2022, 49(09): 913-922.
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http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2022.22.0012
http://www.zlfzyj.com/EN/Y2022/V49/I09/913
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WANG Yue
ZHAO Weizhe
LI Xiaojie
NAN Mengdie
XIE Meiwen
LI Peijin
HOU Li
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