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Research Progress of M2-type Tumor-associated Macrophages in Lung Cancer |
| WAN Xiaoying1,2, ZHOU Songwen1 |
| 1. Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University, Shanghai 200433, China; 2. Medical College of Tongji University, Shanghai 200433, China |
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Abstract Tumor-associated macrophages (TAMs) account for a large proportion in tumor stroma, and can be divided into M1 type (anti-tumoral) and M2 type (pro-tumoral). Recently, many experimental and clinical studies have shown that M2-type TAMs are significantly correlated with tumor stage, tumor cell differentiation, depth of invasion, angiogenesis, lymph node metastasis and therapeutic drug resistance, which eventually affects the prognosis of tumor patients. Targeted TAMs therapy is expected to benefit cancer
patients. This paper reviews the recent research of M2-type TAMs in lung cancer.
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| Keywords
Lung cancer
Tumor-associated macrophages
Tumor microenvironment
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| Fund:Sub-project of Key Project of Shanghai Zhangjiang High-tech Park (No. 2016-08) |
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Issue Date: 14 July 2022
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