Cancer Research on Prevention and Treatment    2022, Vol. 49 Issue (04) : 347-351     DOI: 10.3971/j.issn.1000-8578.2022.21.0994
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Value of Preoperative Lactate Dehydrogenase-to-Albumin Ratio Combined with AFP in Evaluating Prognosis of Patients with Hepatocellular Carcinoma
ZHOU Yongjie1, WANG Zhengfeng2, YAN Jun2, WANG Haiping3, XU Wen4, ZHOU Wence2
1. The First School of Clinical Medical College of Lanzhou University, Lanzhou 730000, China; 2. Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou 730000, China; 3. Key Laboratory of Biotherapy and Regenerative Medicine of Gansu Province, Lanzhou 730000, China; 4. Department of Otolaryngology Head and Neck Surgery, The First Hospital of Lanzhou University, Lanzhou 730000, China
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Abstract Objective To explore the value of preoperative LAR combined with AFP in evaluating the prognosis of patients with HCC. Methods We retrospectively analyzed the clinical data of 106 patients with HCC. Kaplan-Meier method was used to draw the survival curve. Univariate analysis was used to analyze possible variables affecting LAR. Cox risk regression model was used to evaluate the clinical value of preoperative LAR and AFP on the prognosis of HCC patients. Results The DFS and OS of the high LAR group and the high AFP group were shorter than those of the low LAR group and the low AFP group (P<0.05). LAR≥4.58, AFP≥400μg/L and T3-T4 were independent risk factors affecting DFS and OS of HCC patients (P<0.05). Postoperative interventional surgery was an independent factor influencing OS prolongation (P<0.05). The DFS and OS were the shortest in the high LAR and high AFP group, and the DFS and OS were the longest in the low LAR and low AFP group (P<0.05). Conclusion Preoperative LAR and AFP are independent poor prognostic factors of HCC. Preoperative LAR combined with AFP has a certain value in judging the prognosis of HCC patients.
Keywords Hepatocellular carcinoma      Lactate dehydrogenase      Albumin      Alpha-fetoprotein      Prognosis     
ZTFLH:  R735.7  
Issue Date: 15 April 2022
 Cite this article:   
ZHOU Yongjie,WANG Zhengfeng,YAN Jun, et al. Value of Preoperative Lactate Dehydrogenase-to-Albumin Ratio Combined with AFP in Evaluating Prognosis of Patients with Hepatocellular Carcinoma[J]. Cancer Research on Prevention and Treatment, 2022, 49(04): 347-351.
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http://www.zlfzyj.com/EN/Y2022/V49/I04/347
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ZHOU Yongjie
WANG Zhengfeng
YAN Jun
WANG Haiping
XU Wen
ZHOU Wence
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