Cancer Research on Prevention and Treatment    2022, Vol. 49 Issue (01) : 72-77     DOI: 10.3971/j.issn.1000-8578.2022.21.0596
Research Progress on Immunoregulation of Chemotherapeutic Agents
LIU Zhenghao, YANG Chunguang, HU Zhiquan
Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
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Abstract Chemotherapeutic drugs are the mainstay of treatment on mid-advanced tumors. In recent years, more and more studies have shown that chemotherapeutic drugs also have immunomodulatory effects. Some chemotherapeutic drugs can enhance anti-tumor immunity by inducing tumor cell immunogenic cell death or performing “immunogenic modulation”. In addition, chemotherapeutic drugs can also act on immune cells and even the intestinal flora. A number of clinical trials of chemotherapy combined with immune checkpoint inhibitors are currently underway. This article focuses on the immunomodulatory effect of chemotherapeu tic drugs, as well as the potential of chemotherapy combined with ICI on cancer, to provide guidance for the clinical application of chemotherapeutic drugs.
Keywords Antineoplastic; Chemotherapy; Immunomodulation; Gastrointestinal microbiome; Immune checkpoint inhibitors     
ZTFLH:  R730.53  
Issue Date: 11 January 2022
 Cite this article:   
LIU Zhenghao,YANG Chunguang,HU Zhiquan. Research Progress on Immunoregulation of Chemotherapeutic Agents[J]. Cancer Research on Prevention and Treatment, 2022, 49(01): 72-77.
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LIU Zhenghao
YANG Chunguang
HU Zhiquan
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